Matricardi Pietro, Pontoriero Marilena, Coviello Tommasina, Casadei Maria Antonietta, Alhaique Franco
Department of Chemistry and Technology of Biologically Active Compounds, Faculty of Pharmacy, Sapienza University of Rome, Rome, Italy.
Biomacromolecules. 2008 Jul;9(7):2014-20. doi: 10.1021/bm800252c. Epub 2008 Jun 18.
In situ polymerizable hydrogels are extensively investigated to implement new biomedical and pharmaceutical approaches. In the present paper a novel polysaccharidic matrix based on calcium alginate (Ca(II)-Alg) hydrogel and dextran methacrylate derivative (Dex-MA), showing potential applicability in the field of pharmaceutics is described. The semi-interpenetrating polymer system (semi-IPN) obtained by a dispersion of Dex-MA chains into a Ca(II) hydrogel leads to a hydrogel with rheological properties quite different from those of Ca(II)-Alg, allowing to inject the semi-IPN easily through an hypodermic needle. The UV curing of the semi-IPN, by cross-linking of the methacrylate moieties, leads to an IPN strong hydrogel that can be used for a modulated delivery of bioactive molecules. In the present paper, rheological and mechanical behaviors of the semi-IPN and of the IPN are discussed. The release of model molecules, including a protein, are also presented to show the suitability of the novel system as a drug delivery system.
可原位聚合水凝胶被广泛研究以实现新的生物医学和制药方法。本文描述了一种基于海藻酸钙（Ca(II)-Alg）水凝胶和甲基丙烯酸葡聚糖衍生物（Dex-MA）的新型多糖基质，其在制药领域显示出潜在的适用性。通过将Dex-MA链分散到Ca(II)水凝胶中获得的半互穿聚合物体系（半IPN）导致水凝胶的流变学性质与Ca(II)-Alg的流变学性质有很大不同，从而允许通过皮下注射针轻松注射半IPN。通过甲基丙烯酸酯部分的交联对半IPN进行紫外线固化，得到一种IPN强水凝胶，可用于生物活性分子的调节递送。本文讨论了半IPN和IPN的流变学和力学行为。还展示了包括蛋白质在内的模型分子的释放，以表明该新型体系作为药物递送系统的适用性。
