Giarelli L, Melato M, Laurino L, Peruzzo P, Musse M M, Delendi M
Institute of Pathological Anatomy, University of Trieste, Italy.
IARC Sci Publ. 1991(112):37-43.
The reports of 26,879 autopsies performed at the Institute of Pathological Anatomy at the University of Trieste during 1876-85 (70% of all deaths that occurred in the Province) were examined, and 2563 cases of liver cirrhosis were found. Analysis of the sample allowed us to make the following conclusions: (i) The prevalence of cirrhosis at autopsy is high in Trieste and shows no tendency to decrease, as has been inferred by some clinical studies. (ii) The increasing average age at death over the decade studied appears to be unrelated to the new, early treatments adopted for hepatopathic patients, since a similar yearly increase in mean age at death was seen for the whole population of the Province. The combination of a high incidence of cirrhosis and increasing average age of patients will probably result in an increasing occurrence of hepatocellular carcinoma. (iii) The observed male:female ratio (2.3) is analogous to that of alcohol drinkers in the Province and thus suggests a role of alcohol abuse in the development of cirrhosis. The distribution of markers of hepatitis B virus in the population of Trieste, which is very similar in the two sexes, supports this hypothesis.
对的里雅斯特大学病理解剖研究所1876年至1885年间进行的26879例尸检报告（占该省所有死亡人数的70%）进行了检查，发现了2563例肝硬化病例。对样本的分析使我们得出以下结论：（i）在的里雅斯特，尸检时肝硬化的患病率很高，且没有如一些临床研究推断的那样呈下降趋势。（ii）在所研究的十年中，死亡平均年龄的增加似乎与肝病患者采用的新的早期治疗方法无关，因为该省全体人口的死亡平均年龄也有类似的逐年增加。肝硬化高发病率与患者平均年龄增加相结合，可能会导致肝细胞癌的发病率上升。（iii）观察到的男女比例（2.3）与该省饮酒者的比例相似，因此表明酒精滥用在肝硬化发展中起作用。在的里雅斯特人群中，乙型肝炎病毒标志物的分布在两性中非常相似，支持了这一假设。
