Melato M, Zanconati F
Institute of Anatomia Patologica of the University of Trieste, Italy.
Rev Gastroenterol Peru. 1990;10(3):111-4.
The authors report their data on epidemiology of liver cancer (LC) in Trieste. Because of the high autopsy rate in the Province (the ratio autopsies/deaths is about 70%), the findings allow to draw some conclusions which could be regarded as a paradigm, at least in Northern Italy: 1) At autopsy LC prevalence is about 1.8% and the value has been increasing over the last few years; 2) 95.4% of LC are hepatocellular (HCC) and 92.9% of the latter occur in cirrhotic livers. Patients with HCC and cirrhosis are 6 years younger than those affected by HCC alone. On the basis of the above reported conclusions, the role of liver cirrhosis as preneoplastic condition is discussed.
作者报告了他们在的里雅斯特关于肝癌（LC）流行病学的数据。由于该省尸检率较高（尸检数与死亡数之比约为70%），这些研究结果至少在意大利北部可被视为一种范例，从而得出一些结论：1）尸检时LC患病率约为1.8%，且该数值在过去几年中一直在上升；2）95.4%的LC为肝细胞癌（HCC），其中92.9%发生在肝硬化肝脏中。HCC合并肝硬化的患者比单纯患HCC的患者年轻6岁。基于上述结论，讨论了肝硬化作为癌前病变的作用。
