中国农村老年人的微量元素水平与认知功能
Trace element levels and cognitive function in rural elderly Chinese.
作者信息
Gao Sujuan, Jin Yinlong, Unverzagt Frederick W, Ma Feng, Hall Kathleen S, Murrell Jill R, Cheng Yibin, Shen Jianzhao, Ying Bo, Ji Rongdi, Matesan Janetta, Liang Chaoke, Hendrie Hugh C
机构信息
Department of Medicine, Indiana University School of Medicine, 410 West 10th Street, Suite 3000, Indianapolis, IN 46202, USA.
出版信息
J Gerontol A Biol Sci Med Sci. 2008 Jun;63(6):635-41. doi: 10.1093/gerona/63.6.635.
BACKGROUND
Trace elements are involved in metabolic processes and oxidation-reduction reactions in the central nervous system and could have a possible effect on cognitive function. The relationship between trace elements measured in individual biological samples and cognitive function in an elderly population had not been investigated extensively.
METHODS
The participant population is part of a large cohort study of 2000 rural elderly Chinese persons. Six cognitive assessment tests were used to evaluate cognitive function in this population, and a composite score was created to represent global cognitive function. Trace element levels of aluminum, calcium, cadmium, copper, iron, lead, and zinc were analyzed in plasma samples of 188 individuals who were randomly selected and consented to donating fasting blood. Analysis of covariance models were used to assess the association between each trace element and the composite cognitive score adjusting for demographics, medical history of chronic diseases, and the apolipoprotein E (APOE) genotype.
RESULTS
Three trace elements-calcium, cadmium, and copper-were found to be significantly related to the composite cognitive score. Increasing plasma calcium level was associated with higher cognitive score (p <.0001). Increasing cadmium and copper, in contrast, were significantly associated with lower composite score (p =.0044 and p =.0121, respectively). Other trace elements did not show significant association with the composite cognitive score.
CONCLUSIONS
Our results suggest that calcium, cadmium, and copper may be associated with cognitive function in the elderly population.
背景
微量元素参与中枢神经系统的代谢过程和氧化还原反应，可能对认知功能产生影响。个体生物样本中测得的微量元素与老年人群认知功能之间的关系尚未得到广泛研究。
方法
研究对象是一项针对2000名中国农村老年人的大型队列研究的一部分。使用六项认知评估测试来评估该人群的认知功能，并创建一个综合分数来代表整体认知功能。对随机选取并同意捐献空腹血的188名个体的血浆样本中的铝、钙、镉、铜、铁、铅和锌的微量元素水平进行了分析。采用协方差分析模型评估每种微量元素与综合认知分数之间的关联，并对人口统计学、慢性疾病病史和载脂蛋白E（APOE）基因型进行了校正。
结果
发现三种微量元素——钙、镉和铜——与综合认知分数显著相关。血浆钙水平升高与较高的认知分数相关（p <.0001）。相比之下，镉和铜水平升高与较低的综合分数显著相关（分别为p =.0044和p =.0121）。其他微量元素与综合认知分数未显示出显著关联。
结论
我们的结果表明，钙、镉和铜可能与老年人群的认知功能有关。
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