Rothova Aniki, Schneider Margriet, de Groot-Mijnes Jolanda D F
Department of Ophthalmology, University Medical Center Utrecht, Utrecht, The Netherlands.
Ophthalmology. 2008 Nov;115(11):2062-4. doi: 10.1016/j.ophtha.2008.04.034. Epub 2008 Jun 17.
To report on a human immunodeficiency virus (HIV)-infected patient with uveitis and an intraocular HIV1 RNA load largely exceeding that of plasma and no evidence of other intraocular infectious agents causing uveitis than HIV itself.
Interventional case report.
A 37-year-old male HIV-infected patient with uveitis and no retinal manifestations.
Clinical and laboratory examinations including extensive intraocular fluid analyses for various pathogens and HIV-1 RNA loads in the aqueous and plasma.
Results of aqueous analysis and ophthalmologic features. Correlations between the results of aqueous testing and clinical characteristics.
A 37-year-old patient presented with progressive uveitis. He was positive for HIV-1, and his HIV-1 RNA plasma load was 44,600 copies/mL. His intraocular HIV-1 RNA load was >1,900,000 copies/mL, which largely exceeded his concurrent plasma load. No evidence of infectious agents other than HIV itself was found, and the uveitis reacted promptly to solely the antiretroviral treatment.
Our findings suggest that HIV can locally replicate within the eye and cause an intraocular inflammatory reaction.
报告一例人类免疫缺陷病毒（HIV）感染患者，该患者患有葡萄膜炎，眼内HIV-1 RNA载量大大超过血浆中的载量，且无证据表明除HIV本身外有其他眼内感染因子导致葡萄膜炎。
干预性病例报告。
一名37岁感染HIV的男性患者，患有葡萄膜炎，无视网膜表现。
进行临床和实验室检查，包括对各种病原体进行广泛的眼内液分析以及检测房水和血浆中的HIV-1 RNA载量。
房水分析结果和眼科特征。房水检测结果与临床特征之间的相关性。
一名37岁患者出现进行性葡萄膜炎。他的HIV-1检测呈阳性，其血浆中HIV-1 RNA载量为44,600拷贝/毫升。他的眼内HIV-1 RNA载量>1,900,000拷贝/毫升，大大超过其同时期的血浆载量。未发现除HIV本身外的感染因子证据，且葡萄膜炎仅对抗逆转录病毒治疗迅速产生反应。
我们的研究结果表明，HIV可在眼内局部复制并引起眼内炎症反应。
