Gonnelli S, Caffarelli C, Del Santo K, Cadirni A, Guerriero C, Lucani B, Franci B, Nuti R
Department of Internal Medicine, Endocrine-Metabolic Science and Biochemistry, University of Siena, Policlinico Le Scotte, Viale Bracci 2, 53100, Siena, Italy.
Calcif Tissue Int. 2008 Jul;83(1):55-60. doi: 10.1007/s00223-008-9149-y. Epub 2008 Jun 19.
Body weight is commonly considered a significant predictor of bone mineral density (BMD). Adiponectin, an adipocyte-derived hormone, could modulate BMD. Moreover, recent studies have reported that ghrelin is able to stimulate bone formation. In this study, we investigated any associations of adiponectin and ghrelin serum levels with bone turnover markers and BMD in elderly men. In 137 men aged 55 years and older (mean age 67.4 +/- 5.4 years, mean body mass index [BMI] 26.6 +/- 3.4 kg/m2), we evaluated serum adiponectin, serum ghrelin, body composition (fat mass and lean mass), BMD, bone alkaline phosphatase (ALP), and the carboxy-terminal telopeptide of type I collagen (betaCTX). Ghrelin showed significant correlations with BMD at the femoral neck (r = 0.25, P < 0.01), total femur (r = 0.22, P < 0.05), and whole body (r = 0.18, P < 0.05). However, after adjusting for age, BMI, and calcium intake, the correlation remained significant only for femoral neck BMD. Ghrelin showed a significant correlation with lean mass but not with fat mass and bone turnover markers. Adiponectin showed a positive association with both bone ALP and betaCTX; the correlation between adiponectin and bone ALP (r = 0.25, P < 0.01) remained significant after adjusting for confounding variables. No significant correlations between adiponectin and BMD at all skeletal sites were observed. In conclusion, our study suggests that in elderly Italian men serum ghrelin was significantly associated with femoral neck BMD and that adiponectin was positively associated with bone ALP. Further studies are needed to elucidate the role of adipocytokines in bone metabolism.
体重通常被认为是骨矿物质密度（BMD）的重要预测指标。脂联素是一种脂肪细胞衍生的激素，它可以调节骨矿物质密度。此外，最近的研究报告称，胃饥饿素能够刺激骨形成。在本研究中，我们调查了老年男性血清脂联素和胃饥饿素水平与骨转换标志物及骨矿物质密度之间的关联。在137名年龄在55岁及以上的男性中（平均年龄67.4±5.4岁，平均体重指数[BMI]26.6±3.4kg/m²），我们评估了血清脂联素、血清胃饥饿素、身体成分（脂肪量和瘦体重）、骨矿物质密度、骨碱性磷酸酶（ALP）以及I型胶原羧基末端肽（βCTX）。胃饥饿素与股骨颈骨矿物质密度显著相关（r = 0.25，P < 0.01）、全股骨（r = 0.22，P < 0.05）以及全身骨矿物质密度（r = 0.18，P < 0.05）。然而，在调整年龄、BMI和钙摄入量后，仅股骨颈骨矿物质密度的相关性仍然显著。胃饥饿素与瘦体重显著相关，但与脂肪量和骨转换标志物无关。脂联素与骨ALP和βCTX均呈正相关；在调整混杂变量后，脂联素与骨ALP之间的相关性（r = 0.25，P < 0.01）仍然显著。在所有骨骼部位均未观察到脂联素与骨矿物质密度之间存在显著相关性。总之，我们的研究表明，在老年意大利男性中，血清胃饥饿素与股骨颈骨矿物质密度显著相关，而脂联素与骨ALP呈正相关。需要进一步研究以阐明脂肪细胞因子在骨代谢中的作用。
