Maksud F A N, Kakehasi A M, Guimarães M F B R, Machado C J, Barbosa A J A
Departamento de Clínicas Pediátrica e de Adultos, Escola de Medicina, Universidade Federal de Ouro Preto, Ouro Preto, MG, Brasil.
Departamento do Aparelho Locomotor, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.
Braz J Med Biol Res. 2017 May 18;50(6):e5977. doi: 10.1590/1414-431X20175977.
Generalized bone loss can be considered an extra-articular manifestation of rheumatoid arthritis (RA) that may lead to the occurrence of fractures, resulting in decreased quality of life and increased healthcare costs. The peptide ghrelin has demonstrated to positively affect osteoblasts in vitro and has anti-inflammatory actions, but the studies that correlate ghrelin plasma levels and RA have contradictory results. We aimed to evaluate the correlation between total ghrelin plasma levels, density of ghrelin-immunoreactive cells in the gastric mucosa, and bone mineral density (BMD) in twenty adult women with established RA with 6 months or more of symptoms (mean age of 52.70±11.40 years). Patients with RA presented higher ghrelin-immunoreactive cells density in gastric mucosa (P=0.008) compared with healthy females. There was a positive relationship between femoral neck BMD and gastric ghrelin cell density (P=0.007). However, these same patients presented a negative correlation between plasma ghrelin levels and total femoral BMD (P=0.03). The present results indicate that ghrelin may be involved in bone metabolism of patients with RA. However, the higher density of ghrelin-producing cells in the gastric mucosa of these patients does not seem to induce a corresponding elevation in the plasma levels of this peptide.
全身性骨质流失可被视为类风湿关节炎（RA）的关节外表现，这可能导致骨折的发生，从而降低生活质量并增加医疗成本。胃饥饿素肽已被证明在体外对成骨细胞有积极影响且具有抗炎作用，但关于胃饥饿素血浆水平与类风湿关节炎相关性的研究结果相互矛盾。我们旨在评估20名患有确诊类风湿关节炎且症状持续6个月或更长时间（平均年龄52.70±11.40岁）的成年女性的胃饥饿素血浆总水平、胃黏膜中胃饥饿素免疫反应性细胞密度与骨密度（BMD）之间的相关性。与健康女性相比，类风湿关节炎患者胃黏膜中胃饥饿素免疫反应性细胞密度更高（P = 0.008）。股骨颈骨密度与胃饥饿素细胞密度之间存在正相关关系（P = 0.007）。然而，这些患者的血浆胃饥饿素水平与股骨总骨密度之间呈负相关（P = 0.03）。目前的结果表明，胃饥饿素可能参与类风湿关节炎患者的骨代谢。然而，这些患者胃黏膜中产生胃饥饿素的细胞密度较高，似乎并未导致该肽的血浆水平相应升高。
