Zaichkina S I, Rozanova O M, Akhmadieva A Kh, Aptikaeva G F, Smirnova E N, Sorokina S S, Romanchenko S P, Vakhrusheva O A, Peleshko V N
Aviakosm Ekolog Med. 2008 Jan-Feb;42(1):22-7.
Experiments with exposure of mice to low doses of chronic high-LET radiation were carried out in the radiation field behind the concrete wall of the Serpukhov accelerators of protons with the energy of 70 GeV. The goal was to study dose dependence, radiation adaptive response (AR), and genetic instability. Mice (SHK strain) were irradiated continuously 15, 24 and 31 days which corresponded to the doses of 11.5, 21.5 and 31.5 Gy. Cytogenetic damages were determined using the micronuclear test in marrow polychromatophil erythrocytes. It was shown that all the experimental doses aggravated the cytogenetic damage; however, no AR induction in marrow cells was observed. Males of the F1 generation born from the males irradiated at 11.5 Gy had same level of spontaneous cytogenetic damage as males born from non-irradiated parents. Yet, they displayed an exaggerated sensitivity to additional exposure to 1.5 Gy and no AR induction by the standard gamma-protocol which is indicative of genetic instability.
在谢尔普霍夫70 GeV质子加速器混凝土墙后的辐射场中，对小鼠进行了低剂量慢性高传能线密度辐射照射实验。目的是研究剂量依赖性、辐射适应性反应（AR）和遗传不稳定。对小鼠（SHK品系）连续照射15、24和31天，相应剂量分别为11.5、21.5和31.5 Gy。使用骨髓多染性红细胞微核试验确定细胞遗传学损伤。结果表明，所有实验剂量均加重了细胞遗传学损伤；然而，未观察到骨髓细胞中AR的诱导。11.5 Gy照射雄性小鼠所生F1代雄性小鼠的自发细胞遗传学损伤水平与未照射亲本所生雄性小鼠相同。然而，它们对额外1.5 Gy照射表现出过度敏感性，且未通过标准γ射线方案诱导出AR，这表明存在遗传不稳定。
