Appleton K M, Gunnell D, Peters T J, Ness A R, Kessler D, Rogers P J
School of Psychology, Queen's University, Belfast, 18-30 Malone Road, Belfast BT9 5BP, UK.
Prostaglandins Leukot Essent Fatty Acids. 2008 Jun;78(6):337-42. doi: 10.1016/j.plefa.2008.04.009. Epub 2008 Jun 18.
Previous research suggests that low n-3 long-chain polyunsaturated fatty acid (n-3PUFA) status is associated with higher levels of depression in clinical populations. This analysis aimed to investigate the relationship between depressed mood and n-3PUFA status in a non-clinical population. The analysis was conducted on data collected as part of a large randomized controlled trial investigating the impact of n-3PUFA supplementation on depressed mood in a community-based population. On entry into the trial, data on depressed mood were collected using the Depression, Anxiety and Stress Scales (DASS) and the Beck Depression Inventory (BDI). Plasma concentrations of various n-3PUFAs and n-6 long-chain polyunsaturated fatty acids (n-6PUFAs) were obtained from fasting venous blood samples, and various demographics were also measured. Using regression, there was no evidence of an association between either measure of depressed mood and any of the measures of n-3PUFA status or of n-6PUFA:n-3PUFA ratios. Clear associations were also not found when demographic factors were included in the analyses. These findings suggest that n-3PUFAs may not have a role in the aetiology of minor depression. This is also consistent with the results of other studies that have not demonstrated an association between depressed mood and n-3PUFA status in non-clinical populations and epidemiological studies that have not demonstrated an association between depressed mood and n-3PUFA intake in these populations.
先前的研究表明，在临床人群中，n-3长链多不饱和脂肪酸（n-3PUFA）水平较低与抑郁症程度较高有关。本分析旨在调查非临床人群中情绪低落与n-3PUFA水平之间的关系。该分析的数据来自一项大型随机对照试验，该试验旨在研究补充n-3PUFA对社区人群情绪低落的影响。在进入试验时，使用抑郁、焦虑和压力量表（DASS）以及贝克抑郁量表（BDI）收集情绪低落的数据。从空腹静脉血样本中获取各种n-3PUFA和n-6长链多不饱和脂肪酸（n-6PUFA）的血浆浓度，并测量各种人口统计学数据。通过回归分析，未发现情绪低落的任何测量指标与n-3PUFA水平或n-6PUFA:n-3PUFA比值的任何测量指标之间存在关联。在分析中纳入人口统计学因素时，也未发现明显的关联。这些发现表明，n-3PUFA可能在轻度抑郁症的病因学中不起作用。这也与其他研究结果一致，这些研究未证明非临床人群中情绪低落与n-3PUFA水平之间存在关联，以及流行病学研究未证明这些人群中情绪低落与n-3PUFA摄入量之间存在关联。
