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Dioxins, polychlorinated biphenyls, methyl mercury and omega-3 polyunsaturated fatty acids as biomarkers of fish consumption.二恶英、多氯联苯、甲基汞和 ω-3 多不饱和脂肪酸作为鱼类消费的生物标志物。
Eur J Clin Nutr. 2010 Mar;64(3):313-23. doi: 10.1038/ejcn.2009.147. Epub 2010 Jan 27.
2
Is there a role for n-3 long-chain polyunsaturated fatty acids in the regulation of mood and behaviour? A review of the evidence to date from epidemiological studies, clinical studies and intervention trials.n-3长链多不饱和脂肪酸在情绪和行为调节中是否起作用？对来自流行病学研究、临床研究和干预试验的现有证据的综述。
Nutr Res Rev. 2008 Jun;21(1):13-41. doi: 10.1017/S0954422408998620.
3
Mortality in a cohort with high fish consumption.鱼类高摄入量队列中的死亡率。
Int J Epidemiol. 2008 Oct;37(5):1008-17. doi: 10.1093/ije/dyn117. Epub 2008 Jun 25.
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No clear evidence of an association between plasma concentrations of n-3 long-chain polyunsaturated fatty acids and depressed mood in a non-clinical population.在非临床人群中，没有明确证据表明血浆中n-3长链多不饱和脂肪酸浓度与情绪低落之间存在关联。
Prostaglandins Leukot Essent Fatty Acids. 2008 Jun;78(6):337-42. doi: 10.1016/j.plefa.2008.04.009. Epub 2008 Jun 18.
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Effects of nutritional supplementation with antioxidant vitamins and minerals and fish oil on antioxidant status and psychosocial stress in smokers: an open trial.抗氧化维生素、矿物质及鱼油营养补充剂对吸烟者抗氧化状态及心理社会压力的影响：一项开放性试验。
Clin Exp Med. 2007 Dec;7(4):179-83. doi: 10.1007/s10238-007-0144-y. Epub 2008 Jan 11.
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The role of omega-3 fatty acids in mood disorders.ω-3脂肪酸在情绪障碍中的作用。
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Why fish oils may not always be adequate treatments for depression or other inflammatory illnesses: docosahexaenoic acid, an omega-3 polyunsaturated fatty acid, induces a Th-1-like immune response.为什么鱼油可能并不总是治疗抑郁症或其他炎症性疾病的有效方法：二十二碳六烯酸，一种ω-3多不饱和脂肪酸，会引发类似Th-1的免疫反应。
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Dietary intake of folate, other B vitamins, and omega-3 polyunsaturated fatty acids in relation to depressive symptoms in Japanese adults.日本成年人饮食中叶酸、其他B族维生素和ω-3多不饱和脂肪酸的摄入量与抑郁症状的关系。
Nutrition. 2008 Feb;24(2):140-7. doi: 10.1016/j.nut.2007.10.013. Epub 2007 Dec 3.
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Lack of an association of depression with n-3 polyunsaturated fatty acids in adipose tissue and serum phospholipids in healthy adults.健康成年人脂肪组织和血清磷脂中抑郁症与n-3多不饱和脂肪酸之间缺乏关联。
Pharmacol Biochem Behav. 2008 Mar;89(1):6-10. doi: 10.1016/j.pbb.2007.10.015. Epub 2007 Oct 30.
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Genetic and environmental contributions to food use patterns of young adult twins.遗传和环境因素对年轻成年双胞胎食物消费模式的影响。
Physiol Behav. 2008 Jan 28;93(1-2):235-42. doi: 10.1016/j.physbeh.2007.08.025. Epub 2007 Sep 5.

鱼类摄入和多不饱和脂肪酸与心理困扰的关系。

Fish consumption and polyunsaturated fatty acids in relation to psychological distress.

机构信息

National Institute for Health and Welfare (THL), Department of Environmental Health, Kuopio, Finland.

出版信息

Int J Epidemiol. 2010 Apr;39(2):494-503. doi: 10.1093/ije/dyp386. Epub 2010 Feb 15.

DOI:10.1093/ije/dyp386
PMID:20156998
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2846446/
Abstract

BACKGROUND

It has been suggested that high fish consumption improves mental well-being. The aim of this study was to assess whether high fish consumption or omega-3 polyunsaturated fatty acid (PUFA) intake was associated with reduced self-reported psychological distress.

METHODS

We used three cross-sectional data sets, the nationwide Health 2000 Survey (n = 5840), the Fishermen Study on Finnish fishermen and their family members (n = 1282) and the Finntwin16 Study on young adults (n = 4986). Data were based on self-administered questionnaires, interviews, health examinations and blood samples. Psychological distress was measured using the 12-item and 21-item General Health Questionnaires (GHQs). Fish consumption was measured by a food frequency questionnaire (FFQ, g/day) and independent frequency questions (times/month). Dietary intake (g/day) and serum concentrations (% from fatty acids) of PUFAs were determined. Relationships were analysed using regression analysis.

RESULTS

Regardless of the measure, fish consumption and omega-3 PUFA dietary intake were not associated with distress in any of the data sets. In contrast to the hypothesis, high serum docosahexaenoic acid was associated with high distress in the Fisherman Study men. Some non-linear associations were detected between serum omega-3 PUFAs or fish consumption (times/month) and distress. In the Fishermen Study, the associations were modified by alcohol consumption, smoking and physical activity.

CONCLUSIONS

Our results do not support the hypothesis that fish consumption or omega-3 PUFA intake are associated with reduced psychological distress in the general population or in a population with high fish consumption.

摘要

背景

有研究表明，高鱼类摄入量可改善心理健康。本研究旨在评估高鱼类摄入量或 ω-3 多不饱和脂肪酸（PUFA）的摄入是否与减少自我报告的心理困扰有关。

方法

我们使用了三个横断面数据集，即全国健康 2000 调查（n=5840）、芬兰渔民及其家庭成员的渔民研究（n=1282）和芬兰双胞胎 16 岁研究（n=4986）。数据基于自我管理的问卷、访谈、健康检查和血液样本。使用 12 项和 21 项一般健康问卷（GHQ）测量心理困扰。通过食物频率问卷（FFQ，g/天）和独立频率问题（次/月）测量鱼类摄入量。PUFA 的饮食摄入量（g/天）和血清浓度（占脂肪酸的百分比）。使用回归分析分析关系。

结果

无论采用哪种测量方法，在任何数据集中，鱼类摄入量和 ω-3PUFA 的饮食摄入量均与困扰无关。与假设相反，在渔民研究男性中，高血清二十二碳六烯酸与高困扰有关。在血清 ω-3PUFA 或鱼类摄入量（次/月）和困扰之间检测到一些非线性关联。在渔民研究中，这些关联受酒精摄入、吸烟和体力活动的影响。

结论

我们的结果不支持高鱼类摄入量或 ω-3PUFA 摄入与一般人群或高鱼类摄入量人群中心理困扰减少相关的假设。