Leinonen Maarit, Kotaniemi-Talonen Laura, Anttila Ahti, Dyba Tadeusz, Tarkkanen Jussi, Nieminen Pekka
Mass Screening Registry, Finnish Cancer Registry, Pieni Roobertinkatu 9, FI-00130 Helsinki, Finland.
Int J Cancer. 2008 Sep 15;123(6):1344-9. doi: 10.1002/ijc.23670.
A persistent high-risk human papillomavirus (hrHPV) infection is a necessary condition for developing a cervical intraepithelial neoplasia and cervical cancer. The viral aetiology in cervical carcinogenesis has stimulated attempts to use HPV DNA detection in cervical cancer screening. In Finland there is an ongoing study assessing the benefits of primary HPV DNA testing in the setting of centrally organised mass screening for cervical cancer. Here we present the age-specific prevalence of hrHPV infection and associated sociodemographic factors of 16,895 women aged 25-65 years attending the 5-yearly cervical cancer screening between years 2003 and 2004. The overall hrHPV prevalence rate was 7.5%. The peak prevalence at the age group of 25-29 was 24.1% decreasing steadily thereafter to approximately 2.9% in women aged 65 years. Young age and marital status were the main determinants for oncogenic HPV types. Our study confirms the inverse relationship between age and hrHPV prevalence reported in many developed countries. As our prevalence rates and hence background risk for cervical cancer are not lower than in other European countries, it is likely that our lowest cervical cancer burden in Europe is due to health care actions justifying the organised cervical cancer screening.
持续性高危型人乳头瘤病毒（hrHPV）感染是发生宫颈上皮内瘤变和宫颈癌的必要条件。宫颈癌发生中的病毒病因学促使人们尝试在宫颈癌筛查中进行HPV DNA检测。在芬兰，一项正在进行的研究评估了在集中组织的宫颈癌大规模筛查中进行初次HPV DNA检测的益处。在此，我们呈现了2003年至2004年间参加每5年一次宫颈癌筛查的16895名25至65岁女性的hrHPV感染年龄特异性患病率及相关社会人口学因素。总体hrHPV患病率为7.5%。25至29岁年龄组的患病率峰值为24.1%，此后稳步下降，65岁女性中约为2.9%。年轻和婚姻状况是致癌性HPV类型的主要决定因素。我们的研究证实了许多发达国家报道的年龄与hrHPV患病率之间的负相关关系。由于我们的患病率以及因此宫颈癌的背景风险并不低于其他欧洲国家，欧洲最低的宫颈癌负担很可能归因于有组织的宫颈癌筛查所采取的医疗保健措施。
