Kulhan Mehmet, Kulhan Nur G, Seven Yasemin, Nayki Umit A, Nayki Cenk, Ata Nahit, Ulug Pasa
Erzincan University Medical Faculty, Gynaecology and Obstetrics Department, Erzincan, Turkey.
Ministry of Health, Public Health Directorate of Cancer Early Detection, Screening and Training Center, Turkey.
Contemp Oncol (Pozn). 2017;21(3):218-223. doi: 10.5114/wo.2017.69591. Epub 2017 Sep 29.
The present study aims to estimate the prevalence and distribution of HPV genotypes and identify related risk factors among Turkish women.
11 624 Turkish women attending our gynaecological clinic and expressing a desire for access to cervical cancer screening were assessed during the years 2014-2016. Cervical specimens were collected and transported using the HC2 HPV DNA Collection Device (consisting of a cervical brush and digene Specimen Transport Medium).
Among these 11 624 individuals, positive HPV test results were obtained for 325 (2.79%), and negative results were observed for 11 299 (97.2%). The vast majority of patients were between the 3 and 5 decades and the mean age of the patients was 44 ±9.12 (range 27-66). Among the HPV-positive women, 205 were positive for a single HPV type (205/325 = 63.1% of HPV infections; 205/11624 = 1.76% of all samples) and 120 were positive for multiple types (120/325 = 36.9% of HPV infections; 120/11624 = 1.03% of all samples). The four most prevalent high-risk types were HPV 16, 31, 51 and 52, with frequencies of 11.25%, 7.83%, 6.06% and 3.16%, respectively.
There appears to be geographic variation in the distribution of HPV genotypes. In this study, the four most prevalent high-risk types were HPV 16, 31, 51 and 52, with frequencies of 11.25%, 7.83%, 6.06% and 3.16%, respectively.
本研究旨在评估土耳其女性中HPV基因型的流行率和分布情况，并确定相关风险因素。
2014年至2016年期间，对11624名到我们妇科诊所就诊且希望接受宫颈癌筛查的土耳其女性进行了评估。使用HC2 HPV DNA采集装置（由宫颈刷和digene样本运输培养基组成）收集并运输宫颈样本。
在这11624名个体中，325人（2.79%）HPV检测结果为阳性，11299人（97.2%）检测结果为阴性。绝大多数患者年龄在30至50岁之间，患者的平均年龄为44±9.12岁（范围为27至66岁）。在HPV阳性女性中，205人感染单一HPV类型呈阳性（205/325 = HPV感染的63.1%；205/11624 = 所有样本的1.76%），120人感染多种类型呈阳性（120/325 = HPV感染的36.9%；120/11624 = 所有样本的1.03%）。四种最常见的高危类型是HPV 16、31、51和52，频率分别为11.25%、7.83%、6.06%和3.16%。
HPV基因型的分布似乎存在地域差异。在本研究中，四种最常见的高危类型是HPV 16、31、51和52，频率分别为11.25%、7.83%、6.06%和3.16%。
