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本文引用的文献

1
A novel mutation in the human aromatase gene: insights on the relationship among serum estradiol, longitudinal growth and bone mineral density in an adult man under estrogen replacement treatment.人类芳香化酶基因的一种新突变：对接受雌激素替代治疗的成年男性血清雌二醇、纵向生长和骨密度之间关系的见解。
Bone. 2008 Sep;43(3):628-35. doi: 10.1016/j.bone.2008.05.011. Epub 2008 May 23.
2
Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts.雌激素通过雌激素受体α及诱导破骨细胞中的Fas配体来预防骨质流失。
Cell. 2007 Sep 7;130(5):811-23. doi: 10.1016/j.cell.2007.07.025.
3
Skeletal involution by age-associated oxidative stress and its acceleration by loss of sex steroids.年龄相关的氧化应激导致骨骼退化，而性激素丧失会加速这种退化。
J Biol Chem. 2007 Sep 14;282(37):27285-27297. doi: 10.1074/jbc.M702810200. Epub 2007 Jul 10.
4
Osteocyte messages from a bony tomb.来自骨墓的骨细胞信息。
Cell Metab. 2007 Jun;5(6):410-1. doi: 10.1016/j.cmet.2007.05.008.
5
Effect of blockade of TNF-alpha and interleukin-1 action on bone resorption in early postmenopausal women.肿瘤坏死因子-α和白细胞介素-1作用阻断对绝经后早期女性骨吸收的影响。
J Bone Miner Res. 2007 May;22(5):724-9. doi: 10.1359/jbmr.070207.
6
Estradiol, testosterone, and the risk for hip fractures in elderly men from the Framingham Study.来自弗雷明汉研究的老年男性体内的雌二醇、睾酮与髋部骨折风险
Am J Med. 2006 May;119(5):426-33. doi: 10.1016/j.amjmed.2005.10.048.
7
The role of T lymphocytes in bone metabolism.T淋巴细胞在骨代谢中的作用。
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8
Relationship of volumetric BMD and structural parameters at different skeletal sites to sex steroid levels in men.男性不同骨骼部位的体积骨密度和结构参数与性类固醇水平的关系。
J Bone Miner Res. 2005 May;20(5):730-40. doi: 10.1359/JBMR.041228. Epub 2004 Dec 20.
9
Estrogens are essential for male pubertal periosteal bone expansion.
J Clin Endocrinol Metab. 2004 Dec;89(12):6025-9. doi: 10.1210/jc.2004-0602.
10
Raloxifene treatment is associated with increased serum estradiol and decreased bone remodeling in healthy middle-aged men with low sex hormone levels.雷洛昔芬治疗与性激素水平低的健康中年男性血清雌二醇升高及骨重塑减少有关。
J Bone Miner Res. 2004 Sep;19(9):1518-24. doi: 10.1359/JBMR.040503. Epub 2004 May 3.

雌激素与骨骼：来自雌激素抵抗、芳香化酶缺乏及正常男性的见解。

Estrogen and bone: insights from estrogen-resistant, aromatase-deficient, and normal men.

作者信息

Khosla Sundeep

出版信息

Bone. 2008 Sep;43(3):414-7. doi: 10.1016/j.bone.2008.05.005. Epub 2008 May 16.

DOI:10.1016/j.bone.2008.05.005
PMID:18567553
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2553890/
Abstract

Findings from estrogen-resistant and aromatase-deficient men have provided important insights into the role of estrogen in the male skeleton during growth. Importantly, as reported elsewhere in this issue, these data also suggested dose-response relationships between estrogen and bone turnover. In addition, studies in these unusual patients have stimulated research on defining the role of estrogen in regulating bone metabolism in normal adult and aging men, providing further insights into estrogen regulation of bone metabolism not only in men, but also in women.

摘要

对雌激素抵抗和芳香化酶缺乏男性的研究结果，为了解雌激素在男性生长过程中骨骼的作用提供了重要见解。重要的是，正如本期其他地方所报道的，这些数据还表明了雌激素与骨转换之间的剂量反应关系。此外，对这些特殊患者的研究激发了关于确定雌激素在正常成年男性和老年男性骨骼代谢调节中作用的研究，这不仅为雌激素在男性骨骼代谢中的调节作用，也为其在女性骨骼代谢中的调节作用提供了进一步的见解。