Sritharen Yoginee, Enriquez-Sarano Maurice, Schaff Hartzell V, Casaclang-Verzosa Grace, Miller Jordan D
Department of Cardiovascular Surgery, Mayo Clinic, Rochester, Minnesota.
Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota.
Physiology (Bethesda). 2017 May;32(3):182-196. doi: 10.1152/physiol.00025.2016.
Our understanding of the fundamental biology and identification of efficacious therapeutic targets in aortic valve stenosis has lagged far behind the fields of atherosclerosis and heart failure. In this review, we highlight the most clinically relevant problems facing men and women with fibrocalcific aortic valve stenosis, discuss the fundamental biology underlying valve calcification and fibrosis, and identify key molecular points of intersection with sex hormone signaling.
我们对主动脉瓣狭窄的基础生物学的理解以及有效治疗靶点的识别，远远落后于动脉粥样硬化和心力衰竭领域。在本综述中，我们重点介绍患有纤维钙化性主动脉瓣狭窄的男性和女性所面临的最具临床相关性的问题，讨论瓣膜钙化和纤维化的基础生物学，并确定与性激素信号传导的关键分子交叉点。
