Kumar M, Morgan R, Szapocznik J, Eisdorfer C
Center For Biopsychosocial Studies on AIDS, University of Miami, School of Medicine, Florida 33101.
J Acquir Immune Defic Syndr (1988). 1991;4(8):782-6.
Norepinephrine response to a cold pressor test was investigated in 95 homosexual men in a longitudinal study of human immunodeficiency virus (HIV) infection. The baseline data obtained from 76 HIV+ and 19 HIV- subjects are included in this report. After the insertion of a venicatheter and following a 30 min rest, subjects immersed one of their hands in ice water for 2 min, and serial blood samples were obtained for the determination of catecholamine levels. The results show that the norepinephrine response in HIV+ subjects compared to that of HIV- subjects was blunted. Examination of the responses using linear and quadratic orthogonal polynomials suggested that these differences between the two groups were primarily a function of their rate of increase in norepinephrine levels. It was observed also that in HIV+ subjects, norepinephrine level peaked earlier than that in HIV- subjects. The data suggest that autonomic dysfunction is present in the early stages of HIV infection.
在一项关于人类免疫缺陷病毒（HIV）感染的纵向研究中，对95名同性恋男性进行了去甲肾上腺素对冷加压试验的反应研究。本报告纳入了从76名HIV阳性和19名HIV阴性受试者获得的基线数据。插入静脉导管并休息30分钟后，受试者将一只手浸入冰水中2分钟，并采集系列血样以测定儿茶酚胺水平。结果显示，与HIV阴性受试者相比，HIV阳性受试者的去甲肾上腺素反应减弱。使用线性和二次正交多项式对反应进行检查表明，两组之间的这些差异主要是去甲肾上腺素水平升高速率的函数。还观察到，在HIV阳性受试者中，去甲肾上腺素水平比HIV阴性受试者更早达到峰值。数据表明，自主神经功能障碍存在于HIV感染的早期阶段。
