Petersen H, Biereichel A, Burseg K, Simat T J, Steinhart H
Central Institute of Medical Service German Bundeswehr, Kiel, Germany.
Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2008 Jul;25(7):911-20. doi: 10.1080/02652030701837399.
Bisphenol A diglycidyl ether (BADGE) is widely used as a monomer for coatings and adhesives for food-contact applications. Previous publications indicate that, after migration from packaging into foodstuffs, BADGE undergoes various reactions with unidentified food components. In order to elucidate the fate of BADGE, losses were determined after incubation with different foodstuffs and food components. Food proteins were identified as the main reaction partner with BADGE. Adduct formation was found with nucleophilic side-chains of amino acids. In vitro, cysteine exhibited significant activity. The previously reported occurrence of methylthio-derivatives of BADGE in foodstuffs was shown to originate from the reaction of BADGE with methionine. BADGE-methylthio derivatives can, therefore, be used as marker substances in foodstuffs for protein reactions with BADGE. The reported results offer a new viewpoint on the evaluation of BADGE migration. The hydrolysis and hydrochlorination derivatives subject to European legislation make up only a fraction of the totally migrated BADGE, and a further concern is that the toxic or allergenic potential of the protein adducts are unknown.
双酚A二缩水甘油醚（BADGE）被广泛用作食品接触应用的涂料和粘合剂的单体。先前的出版物表明，BADGE从包装迁移到食品中后，会与未鉴定的食品成分发生各种反应。为了阐明BADGE的去向，在与不同食品和食品成分孵育后测定了其损失情况。食品蛋白质被确定为与BADGE反应的主要伙伴。发现与氨基酸的亲核侧链形成加合物。在体外，半胱氨酸表现出显著活性。先前报道的食品中BADGE甲硫基衍生物的出现被证明源于BADGE与蛋氨酸的反应。因此，BADGE-甲硫基衍生物可作为食品中蛋白质与BADGE反应的标志物。报告的结果为评估BADGE迁移提供了新的视角。受欧洲法规监管的水解和氢氯化衍生物仅占完全迁移的BADGE的一小部分，另一个令人担忧的问题是蛋白质加合物的毒性或致敏潜力尚不清楚。
