Kalu Emmanuel, Panay Nick
Reproductive Medicine, Chelsea and Westminster Hospital, London, UK.
Gynecol Endocrinol. 2008 May;24(5):273-9. doi: 10.1080/09513590801990764.
Premature ovarian failure (POF) generally describes a syndrome consisting of amenorrhea, sex steroid deficiency, and elevated/menopausal levels of ganadotropins in a woman aged more than two standard deviations below the mean age at menopause estimated for the reference population. Numerous questions relating to this condition remain unanswered, and several important management issues are yet to be addressed. The challenges posed by this important condition range from difficulties with nomenclature to the absence of standardized diagnostic criteria and management guidelines. In the present paper we discuss the management of spontaneous premature ovarian failure, highlight the challenging issues, review the current literature and propose a practical management outline based on our local practice. Women with POF have unique needs that require special attention. There is an urgent need for a more suitable terminology and evidence-based guidelines on which to establish the diagnosis and manage this difficult condition.
卵巢早衰（POF）通常指一种综合征，在年龄比参考人群绝经平均年龄低两个标准差以上的女性中，表现为闭经、性类固醇缺乏以及促性腺激素水平升高/达到绝经水平。关于这种病症仍有许多问题未得到解答，一些重要的管理问题也有待解决。这一重要病症带来的挑战包括从命名困难到缺乏标准化诊断标准和管理指南等诸多方面。在本文中，我们讨论特发性卵巢早衰的管理，强调具有挑战性的问题，回顾当前文献，并根据我们当地的实践提出一个实用的管理大纲。POF女性有独特的需求，需要特别关注。迫切需要更合适的术语和基于证据的指南来建立诊断和管理这一棘手病症。
