Meskhi Apollo, Seif Mourad W
Academic Unit of Obs & Gynae, University of Manchester, St Mary's Hospital, Manchester, UK.
Curr Opin Obstet Gynecol. 2006 Aug;18(4):418-26. doi: 10.1097/01.gco.0000233937.36554.d3.
To summarize current knowledge about premature ovarian failure (POF) with an emphasis on recent developments regarding its management.
The incidence of POF is increasing largely due to improved survival rates of cancer patients treated with radiation and chemotherapy. Delayed diagnosis and management of POF leads to suboptimal outcomes. Anticipation and early detection of this condition in high-risk women by means of ovarian function testing, followed by early institution of appropriate management could improve outcomes. Choice of strategies should vary depending on the age of onset, associated symptoms and fertility aspirations of the individual, and should change with the patient's advancing age.
Early assessment of the individual's risk of developing POF, development of a strategic management plan, and timely commencement of infertility and hormone deficiency treatment, together with counselling in an integrated management plan should improve both the short and long-term health of those with POF.
总结目前关于卵巢早衰（POF）的知识，重点关注其治疗方面的最新进展。
卵巢早衰的发病率在不断上升，这主要归因于接受放疗和化疗的癌症患者生存率的提高。卵巢早衰的诊断和治疗延迟会导致不理想的结果。通过卵巢功能测试在高危女性中预测和早期发现这种情况，随后尽早进行适当的治疗可以改善结果。治疗策略的选择应根据发病年龄、相关症状以及个体的生育愿望而有所不同，并且应随着患者年龄的增长而变化。
对个体发生卵巢早衰风险的早期评估、制定战略管理计划、及时开始不孕和激素缺乏治疗，以及在综合管理计划中进行咨询，应能改善卵巢早衰患者的短期和长期健康状况。
