Berryman Lyndsey, Czuprynski Charles J
Department of Pathobiological Sciences, School of Veterinary Medicine, College of Agriculture and Life Sciences, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.
Immunopharmacol Immunotoxicol. 2008;30(2):217-26. doi: 10.1080/08923970801946873.
It was recently reported that the aryl hydrocarbon receptor (AhR) plays a role in innate immunity to Listeria monocytogenes infection in mice. In this study the authors analyzed whether incubation of murine macrophages with various flavonoids that have agonist or antagonist activity for the AhR (beta-naphthoflavone, alpha-naphthoflavone, quercetin, luteolin) affect the uptake and survival of L. monocytogenes. Using the RAW264.7 and J774 murine macrophage cell lines and bone marrow-derived macrophages, the authors found no significant difference between flavonoid-treated and control macrophages. They also found that macrophages incubated with flavonoids alone did not exhibit a significant increase in release of tumor necrosis factor (TNF)-alpha, a crucial cytokine in anti-Listeria resistance.
最近有报道称，芳烃受体（AhR）在小鼠对单核细胞增生李斯特菌感染的固有免疫中发挥作用。在本研究中，作者分析了用对AhR具有激动剂或拮抗剂活性的各种黄酮类化合物（β-萘黄酮、α-萘黄酮、槲皮素、木犀草素）孵育小鼠巨噬细胞是否会影响单核细胞增生李斯特菌的摄取和存活。使用RAW264.7和J774小鼠巨噬细胞系以及骨髓来源的巨噬细胞，作者发现黄酮类化合物处理的巨噬细胞与对照巨噬细胞之间没有显著差异。他们还发现，仅用黄酮类化合物孵育的巨噬细胞在肿瘤坏死因子（TNF）-α（抗李斯特菌抗性中的一种关键细胞因子）的释放方面没有显著增加。
