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新型5,7-二芳基-4,4-二甲基-4,5,6,7-四氢吡啶并[3,4-d]-1,2,3-硒二唑的设计、合成、表征、抗菌和抗真菌活性

Design, synthesis, characterization, antibacterial and antifungal activities of a novel class of 5,7-diaryl-4,4-dimethyl-4,5,6,7-tetrahydropyridino[3,4-d]-1,2,3-selenadiazoles.

作者信息

Gopalakrishnan M, Sureshkumar P, Thanusu J, Kanagarajan V

机构信息

Synthetic Organic Chemistry Laboratory, Department of Chemistry, Annamalai University, Tamil Nadu, India.

出版信息

J Enzyme Inhib Med Chem. 2008 Jun;23(3):347-51. doi: 10.1080/14756360701611498.

Abstract

Compound 26 is more potent against Escherichia coli. and 24 is more active against Staphylococcus aureus, beta-Heamolytic streptococcus, Vibreo cholerae, Salmonella typhii, and Shigella flexneri than the standard drug ciprofloxacin. Moreover, of all the compounds tested, 26 is more effective against Aspergillus flavus and Mucor, than the standard drug fluconazole.

摘要

化合物26对大肠杆菌更具效力。并且与标准药物环丙沙星相比,化合物24对金黄色葡萄球菌、β-溶血性链球菌、霍乱弧菌、伤寒沙门氏菌和福氏志贺氏菌更具活性。此外,在所有测试的化合物中,与标准药物氟康唑相比,化合物26对黄曲霉和毛霉更有效。

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