Gopalakrishnan M, Sureshkumar P, Thanusu J, Kanagarajan V
Synthetic Organic Chemistry Laboratory, Department of Chemistry, Annamalai University, Tamil Nadu, India.
J Enzyme Inhib Med Chem. 2008 Jun;23(3):347-51. doi: 10.1080/14756360701611498.
Compound 26 is more potent against Escherichia coli. and 24 is more active against Staphylococcus aureus, beta-Heamolytic streptococcus, Vibreo cholerae, Salmonella typhii, and Shigella flexneri than the standard drug ciprofloxacin. Moreover, of all the compounds tested, 26 is more effective against Aspergillus flavus and Mucor, than the standard drug fluconazole.
化合物26对大肠杆菌更具效力。并且与标准药物环丙沙星相比,化合物24对金黄色葡萄球菌、β-溶血性链球菌、霍乱弧菌、伤寒沙门氏菌和福氏志贺氏菌更具活性。此外,在所有测试的化合物中,与标准药物氟康唑相比,化合物26对黄曲霉和毛霉更有效。