van der Meijden P M, van Klingeren B, Steerenberg P A, de Boer L C, de Jong W H, Debruyne F M
Department of Urology, University Hospital Nijmegen, The Netherlands.
J Urol. 1991 Aug;146(2):444-6. doi: 10.1016/s0022-5347(17)37821-7.
Intravesical treatment with Bacillus Calmette-Guérin is an established treatment of carcinoma in situ and an effective prophylaxis for the prevention of recurrence of transitional cell carcinoma. During instillation therapy oral antibiotics may be used to prevent or to treat urinary tract infections. Tuberculostatic agents are employed to prevent or to treat local irritative symptoms and systemic side effects caused by Bacillus Calmette-Guérin. We investigated the susceptibility of four different Bacillus Calmette-Guérin preparations to 18 antibiotics and to 11 tuberculostatic agents in vitro. All preparations were equally susceptible to most of the commonly used antibiotics and to all of the tuberculostatic agents with the exception of pyrazinamide. Our results suggest that in the absence of cystitis, instillations should not be accompanied by antibiotics because of the possible inhibition of antitumor efficacy by eradication of living Bacillus Calmette-Guérin organisms. The same inhibition may occur when tuberculostatic agents are used to prevent local and systemic complications of Bacillus Calmette-Guérin instillation therapy.
卡介苗膀胱内灌注治疗是原位癌的既定治疗方法，也是预防移行细胞癌复发的有效预防措施。在灌注治疗期间，可使用口服抗生素预防或治疗尿路感染。使用抗结核药预防或治疗卡介苗引起的局部刺激症状和全身副作用。我们在体外研究了四种不同卡介苗制剂对18种抗生素和11种抗结核药的敏感性。除吡嗪酰胺外，所有制剂对大多数常用抗生素和所有抗结核药的敏感性相同。我们的结果表明，在没有膀胱炎的情况下，由于根除活的卡介苗可能会抑制抗肿瘤疗效，灌注不应同时使用抗生素。当使用抗结核药预防卡介苗灌注治疗的局部和全身并发症时，可能会出现同样的抑制作用。
