Yoshioka H, Koyama K, Sato Y, Tanaka J, Matsushiro T, Yamazaki T
Department of Surgery, Akita University School of Medicine, Japan.
Nihon Shokakibyo Gakkai Zasshi. 1991 Apr;88(4):1089-96.
It is well known that the patients with anomalous arrangement of pancreatobiliary duct (AAPBD) are combined with biliary tract cancer. To clarify possible carcinogenesis of the gallbladder with AAPBD, DNA analysis of the gallbladder epithelium was performed in control (9 cases), AAPBD (26), gallbladder cancer confined in mucosa (10) and noncancerous epithelium around the gallbladder cancer (21). The mean values of DNA score, as already reported by us as an indicator of cell kinetics, were 12.1 (control), 27.2 (AAPBD, Type a), 13.3 (AAPBD, Type b), 14.8 (noncancerous epithelium around cancer) and 77.2 (gallbladder cancer confined in mucosa). The values of DNA score in the epithelium of AAPBD (Type a) showed significantly high level, which was next to that of cancer. Type a AAPBD may be supposed to have potential malignancy because of its accelerated cell cycle. But as Type b AAPBD without accelerated cell cycle combines cancer at least as often as Type a, further studies should be performed to reveal the relationship between cell cycle and malignancy.
众所周知，胰胆管异常排列（AAPBD）患者合并有胆道癌。为了阐明AAPBD患者胆囊可能的致癌机制，对对照组（9例）、AAPBD患者（26例）、局限于黏膜层的胆囊癌患者（10例）以及胆囊癌周围的非癌上皮组织（21例）进行了胆囊上皮细胞的DNA分析。我们之前已报道，DNA评分平均值作为细胞动力学指标，在对照组为12.1，AAPBD（a型）为27.2，AAPBD（b型）为13.3，癌周围非癌上皮组织为14.8，局限于黏膜层的胆囊癌为77.2。AAPBD（a型）上皮细胞的DNA评分值显著升高，仅次于癌症。由于a型AAPBD细胞周期加速，可能被认为具有潜在恶性。但由于b型AAPBD细胞周期未加速，其合并癌症的几率至少与a型相同，因此应进一步开展研究以揭示细胞周期与恶性肿瘤之间的关系。
