Tokiwa K, Iwai N, Nakamura K, Okuzumi J, Yamane T, Takahashi T
Division of Surgery, Children's Research Hospital, Kyoto, Japan.
Cancer. 1992 May 15;69(10):2440-3. doi: 10.1002/1097-0142(19920515)69:10<2440::aid-cncr2820691009>3.0.co;2-d.
Ornithine decarboxylase (ODC) activity, which seems to increase in premalignant lesions, was studied in gallbladder mucosa from 32 patients with or without anomalous arrangement of the pancreaticobiliary duct (AAPBD). Mucosal ODC activity was significantly increased in 17 patients with AAPBD compared with 15 control subjects with normal biliary anatomy. Among the 17 patients with AAPBD, ODC activity was significantly increased in 7 in whom the major pancreatic duct joined the common bile duct (P-C type) compared with 8 in whom the common bile duct joined the pancreatic duct (C-P type). The increased ODC activity in gallbladder mucosa suggests that patients with the P-C type of AAPBD may have an increased risk of gallbladder cancer. These results are consistent with recent clinicopathologic studies of AAPBD that have demonstrated an association between AAPBD and biliary tract malignancy. Determination of the mechanism that induces mucosal ODC activity may provide a clue to the pathogenesis of gallbladder carcinoma in patients with AAPBD.
对32例有或无胰胆管异常排列（AAPBD）患者的胆囊黏膜进行了研究，该酶在癌前病变中似乎会增加。与15例胆道解剖结构正常的对照受试者相比，17例AAPBD患者的黏膜鸟氨酸脱羧酶（ODC）活性显著增加。在17例AAPBD患者中，主胰管汇入胆总管的7例（P-C型）ODC活性显著高于胆总管汇入胰管的8例（C-P型）。胆囊黏膜中ODC活性增加表明，P-C型AAPBD患者患胆囊癌的风险可能增加。这些结果与最近关于AAPBD的临床病理研究一致，这些研究表明AAPBD与胆道恶性肿瘤之间存在关联。确定诱导黏膜ODC活性的机制可能为AAPBD患者胆囊癌的发病机制提供线索。
