Kamei J, Mori T, Kasuya Y
Department of Pharmacology, School of Pharmacy, Hoshi University, Tokyo, Japan.
Jpn J Pharmacol. 1991 Mar;55(3):403-6. doi: 10.1254/jjp.55.403.
The effects of L-tryptophan on the development of tolerance to the antitussive effects of dihydrocodeine were examined in rats. Chronic co-administration of L-tryptophan with dihydrocodeine prevented the development of tolerance to the antitussive effects of dihydrocodeine. Furthermore, the antitussive effects of dihydrocodeine in dihydrocodeine-tolerant rats were fully restored by acute co-administration of L-tryptophan, as evidenced by a decrease of about 50% in the ED50 value of dihydrocodeine. Thus, it is concluded that L-tryptophan may antagonized the development of tolerance to the antitussive effects of dihydrocodeine.
在大鼠中研究了L-色氨酸对二氢可待因镇咳作用耐受性发展的影响。L-色氨酸与二氢可待因长期联合给药可预防对二氢可待因镇咳作用耐受性的发展。此外，L-色氨酸急性联合给药可使二氢可待因耐受大鼠中二氢可待因的镇咳作用完全恢复，二氢可待因的半数有效量（ED50）值降低约50%即证明了这一点。因此，得出结论，L-色氨酸可能拮抗对二氢可待因镇咳作用耐受性的发展。
