Copper(I)-promoted synthesis of chloromethyl ketones from trichloromethyl carbinols.
作者信息
Ram Ram N, Manoj T P
机构信息
Department of Chemistry, Indian Institute of Technology, Delhi, Hauz Khas, New Delhi-110016, India.
出版信息
J Org Chem. 2008 Jul 18;73(14):5633-5. doi: 10.1021/jo8007644. Epub 2008 Jun 24.
PMID:18572923
Abstract
Reaction of several trichloromethyl carbinols with 2 equiv of CuCl/bpy in refluxing DCE for 3 h afforded chloromethyl ketones in excellent yield by 1,2-H shift in the copper-chlorocarbenoid intermediate.
摘要
Zotero 插件