Cao Liping, Ding Jiaoyang, Gao Meng, Wang Zihua, Li Juan, Wu Anxin
Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, Central China Normal University, Wuhan 430079, PR China.
Org Lett. 2009 Sep 3;11(17):3810-3. doi: 10.1021/ol901250c.
A novel and direct transformation of aryl, heteroaryl, vinyl, or ethynyl methyl ketones or carbinols to corresponding primary amides has been developed. An iodine-NH(3).H(2)O system was proven to be efficient for this reaction and afforded the expected products with good yields in aqueous media. A tandem Lieben-Haller-Bauer reaction mechanism was involved in this type of reaction and is proposed for the first time.
已开发出一种将芳基、杂芳基、乙烯基或乙炔基甲基酮或甲醇直接转化为相应伯酰胺的新颖方法。事实证明，碘-NH₃·H₂O体系对该反应有效，并且在水性介质中能以良好的产率得到预期产物。这类反应涉及串联的利本-哈勒-鲍尔反应机理，且首次被提出。
