通过使用氨水将甲基酮或甲醇直接转化为伯酰胺的新方法。
Novel and direct transformation of methyl ketones or carbinols to primary amides by employing aqueous ammonia.
作者信息
Cao Liping, Ding Jiaoyang, Gao Meng, Wang Zihua, Li Juan, Wu Anxin
机构信息
Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, Central China Normal University, Wuhan 430079, PR China.
出版信息
Org Lett. 2009 Sep 3;11(17):3810-3. doi: 10.1021/ol901250c.
A novel and direct transformation of aryl, heteroaryl, vinyl, or ethynyl methyl ketones or carbinols to corresponding primary amides has been developed. An iodine-NH(3).H(2)O system was proven to be efficient for this reaction and afforded the expected products with good yields in aqueous media. A tandem Lieben-Haller-Bauer reaction mechanism was involved in this type of reaction and is proposed for the first time.
已开发出一种将芳基、杂芳基、乙烯基或乙炔基甲基酮或甲醇直接转化为相应伯酰胺的新颖方法。事实证明，碘-NH₃·H₂O体系对该反应有效，并且在水性介质中能以良好的产率得到预期产物。这类反应涉及串联的利本-哈勒-鲍尔反应机理，且首次被提出。
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