Vyver Ellie, Steinegger Cathleen, Katzman Debra K
Division of Adolescent Medicine, Department of Paediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada.
Ann N Y Acad Sci. 2008;1135:253-64. doi: 10.1196/annals.1429.013.
Menstrual dysfunction is a common feature of all eating disorders and results in significant medical complications. The etiology of menstrual dysfunction is multifaceted and the result of a complex interplay of many factors including weight loss, decreased body fat, hypoleptinemia, abnormal eating attitudes and behaviors, exercise, and psychological stressors. This chapter will review the prevalence of menstrual dysfunction in adolescents with eating disorders, its multifactorial etiology, the evidence-based pathophysiology, and the resulting complications to linear growth, pubertal development, bone mineral accretion, and cognitive function. Future research directions are identified that suggest opportunities to gain new insights into our understanding of the mechanisms and treatment of menstrual dysfunction in adolescents with eating disorders.
月经功能障碍是所有饮食失调的常见特征，并会导致严重的医学并发症。月经功能障碍的病因是多方面的，是多种因素复杂相互作用的结果，这些因素包括体重减轻、体脂减少、低瘦素血症、异常的饮食态度和行为、运动以及心理压力源。本章将综述饮食失调青少年中月经功能障碍的患病率、其多因素病因、基于证据的病理生理学，以及对线性生长、青春期发育、骨矿物质积累和认知功能产生的并发症。确定了未来的研究方向，这些方向为深入了解饮食失调青少年月经功能障碍的机制和治疗提供了新的见解。
