Fan Hui-min, Zhang Chun-lan, Ying Ruo-su, Chen Zhi-min, Feng Qian-chang
Guangzhou No. 8 People's Hospital, Guangzhou, China.
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2008 Apr;22(2):130-2.
To study the relationship between liver pathological changes and serum HBeAg and HBV DNA in 1057 patients with chronic hepatitis B.
Liver puncture biopsy for histopathological examinations were performed in 1057 patients with chronic hepatitis B. The quantitative analysis of serum HBV DNA by fluorogenic quantitative PCR and HBeAg by chemoluminescence were also conducted.
The inflammatory grade and fibrosis stage were higher in HBeAg-negative patients (G4 and S4 were 7.83% and 12.17% respectively) than in HBeAg-positive patients (G4 and S4 were 3.39% and 5.44% respectively). The inflammatory grade and fibrosis stage were higher in HBeAg-positive patients with low-level HBV DNA (G3G4 was 45.64% and S3S4 was 30.20% for HBV DNA104-105), whereas they were higher in HBeAg-negative patients with high-level HBV DNA (G3G4 was 54.55% for HBV DNA106-107 and S3S4 was 42.85% for HBV DNA108-109).
There were some correlation between the liver pathological changes and serum HBeAg and HBV DNA levels in patients with chronic hepatitis B. It is important to perform the liver pathological examination and antiviral therapy as early as possible in patients with HBeAg-negative chronic hepatitis B.
研究1057例慢性乙型肝炎患者肝脏病理变化与血清HBeAg及HBV DNA的关系。
对1057例慢性乙型肝炎患者进行肝穿刺活检以进行组织病理学检查。同时采用荧光定量PCR对血清HBV DNA进行定量分析，采用化学发光法检测HBeAg。
HBeAg阴性患者的炎症分级和纤维化分期高于HBeAg阳性患者（G4和S4分别为7.83%和12.17%，而HBeAg阳性患者分别为3.39%和5.44%）。低水平HBV DNA的HBeAg阳性患者炎症分级和纤维化分期较高（HBV DNA 10⁴ - 10⁵时，G3G4为45.64%，S3S4为30.20%），而高水平HBV DNA的HBeAg阴性患者炎症分级和纤维化分期较高（HBV DNA 10⁶ - 10⁷时，G3G4为54.55%；HBV DNA 10⁸ - 10⁹时，S3S4为42.85%）。
慢性乙型肝炎患者肝脏病理变化与血清HBeAg及HBV DNA水平之间存在一定相关性。对于HBeAg阴性慢性乙型肝炎患者，尽早进行肝脏病理检查和抗病毒治疗具有重要意义。
