[Ultrastructural changes in the livers of rats following multiple injections of corticotropin and sodium ribonucleinate].

The mechanism of the corticotropin (ACTH) action was studied. It was found that daily injections of ACTH-zinc-phosphate (5 un./100 g) to intact albino rats for 14 days result in a disturbance of the hepatocytes ultrastructure. When the hormone was injected in combination with sodium ribonucleate (5 mg/100 g), the deviations were less pronounced, injections of the hormones to adrenalectomized rats did not change the ultrastructure of hepatocytes.