Pac-Kozuchowska Elzbieta, Zatorska-Karpuś Maria, Kozłowska Maria, Chrzastek-Spruch Hanna
Zakład Propedeutyki Pediatrii AM w Lublinie.
Pediatr Endocrinol Diabetes Metab. 2008;14(1):15-8.
Obesity is the main component of the metabolic syndrome, which appears to be one of the biggest social problems nowadays. The metabolic syndrome can start even in childhood and then risk factors of cardiovascular diseases should be diagnosed and a prophylaxis should be undertaken.
was the evaluation of the selected lipid parameters in the serum in children and adolescents with simple obesity.
The study was conducted on 305 children (156 boys and 149 girls) aged 6.5-17.9 years. The state of nutrition was estimated on the basis of anthropometrical measurements with the evaluation of body weight and height as well as the evaluation of BMI. The obesity was found in 119 children (61 boys and 58 girls) whose BMI was over 95 percentiles. There were 186 children (95 boys and 91 girls) whose BMI was between 25 and 75 percentiles in the control group. In 90 children with the diagnosed simple obesity 10 skinfolds were measured. In all of the studied children concentrations of triglycerides, total cholesterol and HDL cholesterol were determined in the blood serum. The concentration of LDL and VLDL cholesterol were calculated by the Friedewald formula. The obtained research results were analysed statistically. The values of BMI and the lipid parameters among children and adolescents with simple obesity were compared with the control group.
Within the group of boys and girls with obesity higher concentration of total cholesterol (p<0.001) and girls (p<0.05) and LDL cholesterol (p<0.001; p<0.001) were found. However, the significantly lower concentration of HDL cholesterol was found within the girls with obesity in comparison to the control group (p<0.05). The significant negative correlation between the sum of 3 skinfold thickness and concentration of HDL cholesterol were found.
The existence of atherogenic lipids profile in children with obesity allows us to conclude that the children may constitute a group within which there exist risk factors characteristic for the metabolic syndrome.
肥胖是代谢综合征的主要组成部分，而代谢综合征似乎是当今最大的社会问题之一。代谢综合征甚至可能始于儿童期，因此应诊断心血管疾病的危险因素并进行预防。
评估单纯性肥胖儿童和青少年血清中的选定脂质参数。
该研究对305名年龄在6.5至17.9岁之间的儿童（156名男孩和149名女孩）进行。通过人体测量评估营养状况，包括体重和身高评估以及BMI评估。119名儿童（61名男孩和58名女孩）被发现肥胖，其BMI超过第95百分位数。对照组中有186名儿童（95名男孩和91名女孩），其BMI在第25至75百分位数之间。对90名诊断为单纯性肥胖的儿童测量了10处皮褶厚度。在所有研究儿童中测定了血清中的甘油三酯、总胆固醇和高密度脂蛋白胆固醇浓度。低密度脂蛋白和极低密度脂蛋白胆固醇浓度通过Friedewald公式计算。对获得的研究结果进行统计学分析。将单纯性肥胖儿童和青少年的BMI和脂质参数值与对照组进行比较。
在肥胖男孩和女孩组中，发现总胆固醇浓度较高（男孩p<0.001，女孩p<0.05）以及低密度脂蛋白胆固醇浓度较高（男孩p<0.001；女孩p<0.001）。然而，与对照组相比，肥胖女孩组中高密度脂蛋白胆固醇浓度显著较低（p<0.05）。发现3处皮褶厚度总和与高密度脂蛋白胆固醇浓度之间存在显著负相关。
肥胖儿童存在动脉粥样硬化性脂质谱，这使我们能够得出结论，这些儿童可能构成一个存在代谢综合征特征性危险因素的群体。
