Chrzastek-Spruch Hanna, Pac-Kozuchowska Elzbieta
Klinika Patologii Noworodków, Akademia Medyczna, ul. Chodźki 2, 20-092 Lublin, Poland.
Med Wieku Rozwoj. 2003 Apr-Jun;7(2):137-47.
We often observe nutritional disturbances in children and adolescents leading to obesity or cachexy. For evaluating the state of nutrition or the degree of obesity anthropometrics indices are used such as Body Mass Index (BMI). The aim of the study was analysed the concentration of selected indices of lipid metabolism in serum in children and adolescents with relation to BMI.
The examined children were divided into 3 groups: BMI between 10-90 percentiles (186 children), BMI>95 percentiles (27 obese children) and BMI <5 percentiles (17 anorectic girls). In all the studied children concentration of triacyloglycerol, total and HDL cholesterol were assayed in the serum. The level of LDL and VLDL cholesterol was determined with an indirect method. The apolipoproteins:apo-AI and apo-B were assayed in obese children and anorectic girls.
No significant relationship between triacyloglycerol, total cholesterol and cholesterol fractions concentrations and BMI, was found in the group of 186 children (BMI between 10-90 percentiles). Significant positive correlation between BMI and cholesterol LDL in obese children (BMI >95 percentiles) was confirmed (r=0.38, p<0.05). No significant relationship between the lipid parameters and BMI was found in the anorectic girls (BMI< 5 percentiles).
Children with BMI above 95 centile may constitute a group particularly predisposed for early development of atherosclerosis.
我们经常观察到儿童和青少年出现营养紊乱，导致肥胖或恶病质。为评估营养状况或肥胖程度，会使用人体测量学指标，如体重指数（BMI）。本研究的目的是分析儿童和青少年血清中选定脂质代谢指标的浓度与BMI的关系。
将受试儿童分为3组：BMI在第10至90百分位数之间（186名儿童）、BMI>第95百分位数（27名肥胖儿童）和BMI<第5百分位数（17名厌食症女孩）。对所有受试儿童测定血清中的三酰甘油、总胆固醇和高密度脂蛋白胆固醇浓度。用间接法测定低密度脂蛋白和极低密度脂蛋白胆固醇水平。对肥胖儿童和厌食症女孩测定载脂蛋白：载脂蛋白A-I和载脂蛋白B。
在186名儿童组（BMI在第10至90百分位数之间）中，未发现三酰甘油、总胆固醇和胆固醇组分浓度与BMI之间存在显著关系。在肥胖儿童（BMI>第95百分位数）中，证实BMI与低密度脂蛋白胆固醇之间存在显著正相关（r = 0.38，p<0.05）。在厌食症女孩（BMI<第5百分位数）中，未发现脂质参数与BMI之间存在显著关系。
BMI高于第95百分位数的儿童可能是特别易患动脉粥样硬化早期发展的群体。
