Hacham H, Freeman S E, Gange R W, Maytum D J, Sutherland J C, Sutherland B M
Biology Department, Brookhaven National Laboratory, Upton, NY 11973.
Photochem Photobiol. 1991 Apr;53(4):559-63. doi: 10.1111/j.1751-1097.1991.tb03671.x.
Ultraviolet radiation produces erythema in human skin, and damages the DNA of living cells in skin. Previous work showed that broad-band UV-B (290-320 nm) radiation produced higher levels of cyclobutyl pyrimidine dimers in DNA of individuals with high UV-B sensitivity (low minimal erythema dose) than in subjects of low UV-B sensitivity [Freeman et al. (1986) J. Invest. Dermatol., 86, 34-36]. We examined the relationship between erythema induction and dimer yields in DNA of human skin irradiated in situ with narrow band radiation spanning the wavelength range 275-365 nm. We find that, in general, higher dimer yields are produced per incident photon in volunteers with higher susceptibility to erythema induced by radiation of the same wavelength.
紫外线辐射会使人类皮肤产生红斑，并损害皮肤中活细胞的DNA。先前的研究表明，宽带UV-B（290 - 320纳米）辐射在具有高UV-B敏感性（低最小红斑剂量）的个体的DNA中产生的环丁基嘧啶二聚体水平高于低UV-B敏感性的受试者[弗里曼等人（1986年）《皮肤病学研究杂志》，86卷，34 - 36页]。我们研究了原位照射波长范围为275 - 365纳米的窄带辐射的人体皮肤中，红斑诱导与DNA中二聚体产量之间的关系。我们发现，一般来说，对于对相同波长辐射诱导的红斑更敏感的志愿者，每个入射光子产生的二聚体产量更高。
