嘧啶二聚体的产生量与原位接受紫外线（275 - 365纳米）照射的人体皮肤中的红斑形成有关吗？

Do pyrimidine dimer yields correlate with erythema induction in human skin irradiated in situ with ultraviolet light (275-365 nm)?

作者信息

Hacham H, Freeman S E, Gange R W, Maytum D J, Sutherland J C, Sutherland B M

机构信息

Biology Department, Brookhaven National Laboratory, Upton, NY 11973.

出版信息

Photochem Photobiol. 1991 Apr;53(4):559-63. doi: 10.1111/j.1751-1097.1991.tb03671.x.

DOI:10.1111/j.1751-1097.1991.tb03671.x

PMID:1857749

Abstract

Ultraviolet radiation produces erythema in human skin, and damages the DNA of living cells in skin. Previous work showed that broad-band UV-B (290-320 nm) radiation produced higher levels of cyclobutyl pyrimidine dimers in DNA of individuals with high UV-B sensitivity (low minimal erythema dose) than in subjects of low UV-B sensitivity [Freeman et al. (1986) J. Invest. Dermatol., 86, 34-36]. We examined the relationship between erythema induction and dimer yields in DNA of human skin irradiated in situ with narrow band radiation spanning the wavelength range 275-365 nm. We find that, in general, higher dimer yields are produced per incident photon in volunteers with higher susceptibility to erythema induced by radiation of the same wavelength.

摘要

紫外线辐射会使人类皮肤产生红斑，并损害皮肤中活细胞的DNA。先前的研究表明，宽带UV-B（290 - 320纳米）辐射在具有高UV-B敏感性（低最小红斑剂量）的个体的DNA中产生的环丁基嘧啶二聚体水平高于低UV-B敏感性的受试者[弗里曼等人（1986年）《皮肤病学研究杂志》，86卷，34 - 36页]。我们研究了原位照射波长范围为275 - 365纳米的窄带辐射的人体皮肤中，红斑诱导与DNA中二聚体产量之间的关系。我们发现，一般来说，对于对相同波长辐射诱导的红斑更敏感的志愿者，每个入射光子产生的二聚体产量更高。