Donofrio Gaetano, Ravanetti Lara, Cavirani Sandro, Herath Shan, Capocefalo Antonio, Sheldon Iain Martin
Dipartimento di Salute Animale, Facoltà di Medicina Veterinaria, Università di Parma, Sezione di Malattie Infettive degli Animali, via del Taglio 8, 43100 Parma, Italy.
Reproduction. 2008 Sep;136(3):361-6. doi: 10.1530/REP-08-0171. Epub 2008 Jun 24.
Experimental infection with the gamma-herpesvirus bovine herpesvirus 4 (BoHV-4) rarely establishes disease, yet BoHV-4 is commonly associated with uterine disease in cattle. Uterine disease involves co-infection with bacteria such as Escherichia coli, which stimulate the production of prostaglandin E(2) (PGE(2)) by endometrial cells. BoHV-4 replication depends on immediate early 2 (IE2) gene transactivation and, in the present study, PGE(2), E. coli or its lipopolysaccharide upregulated the IE2 gene promoter in uterine cells. Bacterial co-infection is important for BoHV-4 uterine disease.
用γ-疱疹病毒牛疱疹病毒4型(BoHV-4)进行实验性感染很少引发疾病,但BoHV-4通常与牛的子宫疾病有关。子宫疾病涉及与诸如大肠杆菌等细菌的共同感染,这些细菌会刺激子宫内膜细胞产生前列腺素E2(PGE2)。BoHV-4的复制依赖于立即早期2(IE2)基因的反式激活,在本研究中,PGE2、大肠杆菌或其脂多糖上调了子宫细胞中的IE2基因启动子。细菌共同感染对BoHV-4子宫疾病很重要。