Krebs I, Haas P, Zeiler F, Binder S
Department of Ophthalmology, Rudolf Foundation Clinic, Juchgasse 25, 1030 Vienna, Austria.
Br J Ophthalmol. 2008 Jul;92(7):933-5. doi: 10.1136/bjo.2007.128447.
The retinal-mapping program of Stratus optical coherence tomography (Carl Zeiss Meditec, Dublin, CA, USA) calculates the retinal volume of the central region between the retinal surface and the retinal pigment epithelium (RPE). This study evaluates the retinal-mapping program for studies dealing with AMD.
The scans of both eyes of patients examined from August to October 2006 because of macular degeneration were evaluated retrospectively. Independent examiners tested whether the two lines indicating the retinal surface and the RPE were positioned correctly by the threshold algorithm that corresponded with correct measurements.
The scans of 233 eyes of 117 patients were evaluated (39.3% were men and 60.7% women, with a mean age of 76.9 years). Overall, in 57.1% both lines were positioned correctly. False-positioned lines were recorded in 9.0% due to low scan quality and in 33.9% due to a doubled or interrupted hyper-reflective band of the RPE. Threshold algorithm misinterpretation was significantly more frequent in occult lesions with and without fibrosis than in non-exudative lesions, and were significantly correlated to distance acuity (p<0.0001).
The retinal-mapping program for examination of AMD provided correct results in only 57.1% of eyes. A manual correction of false-positioned lines would be needed to improve accuracy.
Stratus光学相干断层扫描（卡尔蔡司医疗技术公司，美国加利福尼亚州都柏林）的视网膜测绘程序可计算视网膜表面与视网膜色素上皮（RPE）之间中央区域的视网膜体积。本研究评估该视网膜测绘程序在与年龄相关性黄斑变性（AMD）相关研究中的应用。
对2006年8月至10月因黄斑变性接受检查的患者双眼扫描结果进行回顾性评估。独立检查人员通过与正确测量结果对应的阈值算法，检测指示视网膜表面和RPE的两条线定位是否正确。
对117例患者的233只眼的扫描结果进行了评估（男性占39.3%，女性占60.7%，平均年龄76.9岁）。总体而言，57.1%的双眼两条线定位正确。由于扫描质量低，9.0%的眼出现定位错误的线；由于RPE的高反射带加倍或中断，33.9%的眼出现定位错误的线。阈值算法误判在有或无纤维化的隐匿性病变中比在非渗出性病变中更频繁，且与远视力显著相关（p<0.0001）。
用于AMD检查的视网膜测绘程序仅在57.1%的眼中提供了正确结果。需要手动校正定位错误的线以提高准确性。
