Montell Craig
Departments of Biological Chemistry and Neuroscience, Center for Sensory Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Neuron. 2008 Jun 26;58(6):825-7. doi: 10.1016/j.neuron.2008.06.006.
Activation of the archetypal Transient Receptor Potential (TRP) channel, which is essential for Drosophila phototransduction, depends on a phospholipase C (PLC). However, the precise mechanism linking PLC to the gating of TRP has been elusive. In this issue of Neuron, Leung et al. provide compelling evidence that a diacylglycerol (DAG) lipase (INAE), acting downstream of the PLC, is essential for opening TRP. These results strongly support the model that a DAG metabolite is critical for TRP activation and suggest that mammalian DAG lipases may play similar roles.
原型瞬时受体电位（TRP）通道的激活对果蝇光转导至关重要，而这一过程依赖于磷脂酶C（PLC）。然而，将PLC与TRP门控联系起来的精确机制一直难以捉摸。在本期《神经元》杂志中，梁等人提供了令人信服的证据，表明在PLC下游起作用的二酰基甘油（DAG）脂肪酶（INAE）对打开TRP至关重要。这些结果有力地支持了DAG代谢物对TRP激活至关重要的模型，并表明哺乳动物DAG脂肪酶可能发挥类似作用。
