寻找果蝇瞬时受体电位通道（TRP）的圣杯。

In search of the holy grail for Drosophila TRP.

作者信息

Montell Craig

机构信息

Departments of Biological Chemistry and Neuroscience, Center for Sensory Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

出版信息

Neuron. 2008 Jun 26;58(6):825-7. doi: 10.1016/j.neuron.2008.06.006.

DOI:10.1016/j.neuron.2008.06.006

PMID:18579072

Abstract

Activation of the archetypal Transient Receptor Potential (TRP) channel, which is essential for Drosophila phototransduction, depends on a phospholipase C (PLC). However, the precise mechanism linking PLC to the gating of TRP has been elusive. In this issue of Neuron, Leung et al. provide compelling evidence that a diacylglycerol (DAG) lipase (INAE), acting downstream of the PLC, is essential for opening TRP. These results strongly support the model that a DAG metabolite is critical for TRP activation and suggest that mammalian DAG lipases may play similar roles.

摘要

原型瞬时受体电位（TRP）通道的激活对果蝇光转导至关重要，而这一过程依赖于磷脂酶C（PLC）。然而，将PLC与TRP门控联系起来的精确机制一直难以捉摸。在本期《神经元》杂志中，梁等人提供了令人信服的证据，表明在PLC下游起作用的二酰基甘油（DAG）脂肪酶（INAE）对打开TRP至关重要。这些结果有力地支持了DAG代谢物对TRP激活至关重要的模型，并表明哺乳动物DAG脂肪酶可能发挥类似作用。