Children's Hospital Oakland Research Institute, Oakland, CA, USA.
Vaccine. 2010 Jan 22;28(4):1121-31. doi: 10.1016/j.vaccine.2008.05.055. Epub 2008 Jun 9.
In September 2007, a meeting entitled 'Carbohydrate Moieties as Vaccine Candidates' was held at the National Institutes of Health (Bethesda, MD). This meeting brought together scientists from a number of disciplines to address issues concerning carbohydrate moieties as targets for vaccines for a variety of pathogens and tumors. In addition, the meeting participants addressed fundamental topics of glycoimmunology including the recognition of glycotopes by B and T lymphocytes, the ontogeny of anti-carbohydrate immune responses, peptide mimicry, carbohydrate antigen processing pathways and adjuvants. One session reported progress in the development of new tools such as computational algorithms, glycan arrays and oligosaccharide synthesis and their application to carbohydrate vaccine research. The session titles were: (1) immune response to bacterial carbohydrate antigens; (2) immune response to glycolipids; (3) immune response to carbohydrate antigens on other microbes and on tumors; (4) novel vaccine approaches; (5) novel tools in carbohydrate vaccine research; (6) bench to bedside: carbohydrate moieties as vaccine immunopotentiators.
2007 年 9 月，在马里兰州贝塞斯达的美国国立卫生研究院（NIH）举行了一次题为“碳水化合物作为疫苗候选物”的会议。这次会议聚集了来自多个学科的科学家，讨论了针对各种病原体和肿瘤的碳水化合物作为疫苗靶点的问题。此外，会议参与者还讨论了糖基免疫学的基本课题，包括 B 和 T 淋巴细胞对糖基的识别、抗碳水化合物免疫反应的个体发生、肽模拟、碳水化合物抗原加工途径和佐剂。有一个会议报告了新工具（如计算算法、聚糖阵列和寡糖合成）的发展进展及其在碳水化合物疫苗研究中的应用。会议的标题是：（1）细菌碳水化合物抗原的免疫反应；（2）糖脂的免疫反应；（3）其他微生物和肿瘤上的碳水化合物抗原的免疫反应；（4）新型疫苗方法；（5）碳水化合物疫苗研究中的新工具；（6）从实验室到病床：碳水化合物作为疫苗免疫增强剂。
