Song Hong Ji, Kim Hwa Jung, Choi Nam-Kyong, Hahn Seokyung, Cho Yong-Jin, Park Byung-Joo
Department of Family Medicine, Hallym University College of Medicine, Chuncheon, Gangwon-do, Korea.
Alcohol. 2008 Aug;42(5):363-8. doi: 10.1016/j.alcohol.2008.04.005. Epub 2008 Jun 24.
Although numerous studies have been done on gastric cancer and alcohol consumption, results from these studies are inconsistent. We conducted a population-based, prospective cohort study to establish a relationship between alcohol and gastric cancer according to gender. The cohort consisted of elderly (>64 years of age) subjects at the baseline of 1993-1998. Baseline information was surveyed using a self-administered questionnaire. Gastric cancers were identified by the National Cancer Registry. Cox proportional hazards models were used to calculate relative risks with 95% confidence intervals. A follow up of 116,997.1 person-years of the 13,396 subjects revealed 151 newly diagnosed gastric cancers (80 men and 71 women). The risk of gastric cancer was higher by a factor of three among female former drinkers (adjusted relative risk 2.85 [95% confidence interval 1.11-7.32]) compared to current and nondrinkers. Female former drinkers showed greater alcohol consumption than current drinkers (36.5g/week vs. 16.4g/week; P<.0001) and a longer duration of alcohol consumption than did current drinkers (24.5 years vs. 18.46 years; P<.0001). Female subjects with more than 110g of weekly alcohol consumption had an increased risk of developing gastric cancer (adjusted relative risk 2.23 [95% confidence interval 0.79-6.29]), although the result was statistically insignificant. No relationship was observed for male subjects. The relationship between alcohol and gastric cancer differs according to gender. Alcohol consumption may increase the risk of gastric cancer in women, and the risk elevation may persist for several years after drinking ceases.
尽管已经针对胃癌与饮酒进行了大量研究，但这些研究的结果并不一致。我们开展了一项基于人群的前瞻性队列研究，以确定酒精与胃癌之间按性别划分的关系。该队列由1993年至1998年基线时的老年（>64岁）受试者组成。基线信息通过自填问卷进行调查。胃癌由国家癌症登记处确定。使用Cox比例风险模型计算相对风险及95%置信区间。对13396名受试者进行了116997.1人年的随访，发现151例新诊断的胃癌（80名男性和71名女性）。与当前饮酒者和不饮酒者相比，女性既往饮酒者患胃癌的风险高出两倍（调整后相对风险2.85 [95%置信区间1.11 - 7.32]）。女性既往饮酒者的饮酒量高于当前饮酒者（36.5克/周 vs. 16.4克/周；P<0.0001），饮酒持续时间也长于当前饮酒者（24.5年 vs. 18.46年；P<0.0001）。每周饮酒量超过110克的女性受试者患胃癌的风险增加（调整后相对风险2.23 [95%置信区间0.79 - 6.29]），尽管该结果在统计学上不显著。男性受试者未观察到相关性。酒精与胃癌之间的关系因性别而异。饮酒可能会增加女性患胃癌的风险，并且在停止饮酒后这种风险升高可能会持续数年。
