Tsubono Y, Nishino Y, Komatsu S, Hsieh C C, Kanemura S, Tsuji I, Nakatsuka H, Fukao A, Satoh H, Hisamichi S
Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
N Engl J Med. 2001 Mar 1;344(9):632-6. doi: 10.1056/NEJM200103013440903.
Although laboratory experiments and case-control studies have suggested that the consumption of green tea provides protection against gastric cancer, few prospective studies have been performed.
In January 1984, a total of 26,311 residents in three municipalities of Miyagi Prefecture, in northern Japan (11,902 men and 14,409 women 40 years of age or older), completed a self-administered questionnaire that included questions about the frequency of consumption of green tea. During 199,748 person-years of follow-up, through December 1992, we identified 419 cases of gastric cancer (in 296 men and 123 women). We used Cox regression to estimate the relative risk of gastric cancer according to the consumption of green tea.
Green-tea consumption was not associated with the risk of gastric cancer. After adjustment for sex, age, presence or absence of a history of peptic ulcer smoking status, alcohol consumption, other dietary elements, and type of health insurance, the relative risks associated with drinking one or two, three or four, and five or more cups of green tea per day, as compared with less than one cup per day, were 1.1 (95 percent confidence interval, 0.8 to 1.6), 1.0 (95 percent confidence interval, 0.7 to 1.4), and 1.2 (95 percent confidence interval, 0.9 to 1.6), respectively (P for trend=0.13). The results were similar after the 117 cases of gastric cancer that were diagnosed in the first three years of follow-up had been excluded, with respective relative risks of 1.2 (95 percent confidence interval, 0.8 to 1.8) 1.0 (95 percent confidence interval, 0.7 to 1.5), and 1.4 (95 percent confidence interval, 1.0 to 1.9) (P for trend=0.07).
In a population-based, prospective cohort study in Japan, we found no association between green-tea consumption and the risk of gastric cancer.
尽管实验室实验和病例对照研究表明饮用绿茶可预防胃癌，但前瞻性研究却很少。
1984年1月，日本北部宫城县三个市的26311名居民（11902名男性和14409名40岁及以上女性）完成了一份自我管理的问卷，其中包括关于绿茶饮用频率的问题。在截至1992年12月的199748人年随访期间，我们确定了419例胃癌病例（296例男性和123例女性）。我们使用Cox回归根据绿茶饮用量估计胃癌的相对风险。
绿茶饮用与胃癌风险无关。在对性别、年龄、是否有消化性溃疡病史、吸烟状况、饮酒量、其他饮食因素和健康保险类型进行调整后，与每天饮用少于一杯绿茶相比，每天饮用一杯或两杯、三杯或四杯、五杯或更多杯绿茶的相对风险分别为1.1（95%置信区间，0.8至1.6）、1.0（95%置信区间，0.7至1.4）和1.2（95%置信区间，0.9至1.6）（趋势P值=0.13）。在排除随访前三年诊断出的117例胃癌病例后，结果相似，相对风险分别为1.2（95%置信区间，0.8至1.8）、1.0（95%置信区间，0.7至1.5）和1.4（95%置信区间，1.0至1.9）（趋势P值=0.07）。
在日本一项基于人群的前瞻性队列研究中，我们发现绿茶饮用与胃癌风险之间没有关联。
