Soni Sushane, Leslie William D
Section of Nuclear Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
Clin Nucl Med. 2008 Jul;33(7):502-4. doi: 10.1097/RLU.0b013e31817792e4.
A 51-year-old woman on peritoneal dialysis for chronic renal failure secondary to diabetic and nonsteroidal anti-inflammatory drug nephropathy was referred for a Tc-99m MDP bone scan to assess firm subcutaneous plaques in the sacral and gluteal regions. This showed extensive superficial tracer localization in the subcutaneous tissues as well as visceral tracer activity in the myocardium, lungs, stomach, and kidneys. These findings were typical for calciphylaxis (calcific uremic arteriolopathy), a form of metastatic calcification encountered in patients with chronic renal failure that is characterized by subcutaneous soft tissue calcification, painful ulcerations, high morbidity, and mortality. Treatment with sodium thiosulfate resulted in dramatic scintigraphic improvement.
一名51岁女性因糖尿病和非甾体抗炎药肾病继发慢性肾衰竭接受腹膜透析，因骶部和臀部区域有坚硬的皮下斑块，被转诊进行锝-99m亚甲基二膦酸盐（Tc-99m MDP）骨扫描。扫描显示皮下组织有广泛的浅表示踪剂定位，以及心肌、肺、胃和肾脏的内脏示踪剂活性。这些发现是钙磷代谢障碍（钙化性尿毒症小动脉病）的典型表现，这是慢性肾衰竭患者中出现的一种转移性钙化形式，其特征为皮下软组织钙化、疼痛性溃疡、高发病率和死亡率。硫代硫酸钠治疗使闪烁扫描结果有显著改善。
