Jain Gaurav, Kumar Vineet, Chakrabarti Subho, Grover Sandeep
Department of Psychiatry, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
J ECT. 2008 Jun;24(2):122-7. doi: 10.1097/YCT.0b013e318160d61e.
There are very little data on elderly patients receiving electroconvulsive therapy (ECT) in India. This study was a preliminary attempt at characterizing the clinical and demographic profile of elderly subjects (>or=60 years) who received ECT in the psychiatric department of a teaching hospital in north India.
A retrospective case-note review was carried out to identify patients 60 years or older who had received ECT over an 8-year period at the Postgraduate Institute of Medical Education and Research, Chandigarh, India. Several details about their demographic and clinical profile, indications for ECT, response patterns, and adverse effects were extracted.
Over the 8 years, 373 patients received ECT, of which 56 (15%) were 60 years or older. Complete records were available for only 50 of these patients. The majority (96%) had depression. The index depressive episode for which ECT was used was severe in 91.6% of the subjects, and 68% had not responded to adequate psychotropic treatment before ECT. Comorbid medical illnesses were present in 66% of cases and were associated with significantly higher risk of cognitive side effects. However, side effects were usually mild; there were no serious untoward events caused by ECT. About 80% to 90% showed some response to treatment. Those who had received inadequate antidepressant treatment before ECT were significantly more likely to respond to ECT.
Elderly with depression constitute a substantial proportion of those receiving ECT in India. Use of ECT in this population seemed to be mainly restricted to those who were very severely ill and poorly responsive to medications. Electroconvulsive therapy seemed to be a safe and effective treatment in such situations. However, particular care may be required in the subgroup with comorbid physical problems that may be more vulnerable to cognitive adverse effects.
在印度,关于老年患者接受电休克治疗(ECT)的数据非常少。本研究是对印度北部一家教学医院精神科接受ECT治疗的老年受试者(≥60岁)的临床和人口统计学特征进行初步描述的尝试。
进行了一项回顾性病例记录审查,以确定在印度昌迪加尔医学教育与研究研究生院8年期间接受ECT治疗的60岁及以上患者。提取了有关他们的人口统计学和临床特征、ECT适应症、反应模式及不良反应的若干细节。
在这8年中,373例患者接受了ECT治疗,其中56例(15%)为60岁及以上。这些患者中只有50例有完整记录。大多数(96%)患有抑郁症。使用ECT治疗的首发抑郁发作在91.6%的受试者中为重度,68%的患者在ECT治疗前对充分的精神药物治疗无反应。66%的病例存在合并内科疾病,且与认知副作用风险显著较高相关。然而,副作用通常较轻;ECT未引起严重不良事件。约80%至90%的患者对治疗有一定反应。ECT治疗前接受抗抑郁治疗不足的患者对ECT治疗有反应的可能性显著更高。
在印度,患有抑郁症的老年人在接受ECT治疗的患者中占很大比例。在这一人群中,ECT的使用似乎主要限于病情非常严重且对药物反应不佳的患者。在这种情况下,电休克治疗似乎是一种安全有效的治疗方法。然而,对于可能更容易出现认知不良反应的合并身体问题的亚组患者,可能需要特别护理。