University of Louisville, Kentucky, USA.
Autism. 2011 Mar;15(2):223-38. doi: 10.1177/1362361310386506. Epub 2011 Mar 1.
Multiple studies suggest that the corpus callosum in patients with autism is reduced in size. This study attempts to elucidate the nature of this morphometric abnormality by analyzing the shape of this structure in 17 high-functioning patients with autism and an equal number of comparison participants matched for age, sex, IQ, and handedness. The corpus callosum was segmented from T1 weighted images acquired with a Siemens 1.5 T scanner. Transformed coordinates of the curvilinear axis were aggregated into a parametric map and compared across series to derive regions of statistical significance. Our results indicate that a reduction in size of the corpus callosum occurs over all of its subdivisions (genu, body, splenium) in patients with autism. Since the commissural fibers that traverse the different anatomical compartments of the corpus callosum originate in disparate brain regions our results suggest the presence of widely distributed cortical abnormalities in people with autism.
多项研究表明，自闭症患者的胼胝体体积减小。本研究试图通过分析 17 名高功能自闭症患者和年龄、性别、智商和利手相匹配的对照组参与者的结构形状来阐明这种形态异常的本质。胼胝体从西门子 1.5T 扫描仪采集的 T1 加权图像中分割出来。曲线轴的变换坐标被聚集到参数图中，并在序列之间进行比较，以得出具有统计学意义的区域。我们的结果表明，自闭症患者的胼胝体所有细分部分（膝部、体部、压部）的体积都减小了。由于穿过胼胝体不同解剖部位的连合纤维起源于不同的脑区，因此我们的结果表明自闭症患者存在广泛分布的皮质异常。
