c/o Department of Intensive Care, Rigshospitalet, Copenhagen, Denmark.
Acta Anaesthesiol Scand. 2008 Jul;52(6):750-8. doi: 10.1111/j.1399-6576.2008.01690.x.
Fluid resuscitation is a frequent intervention in intensive care. Colloids are widely used, but recent data suggest harm by some of these solutions. This calls for more clinical studies on this matter, but the current preferences for colloid use in Scandinavian intensive care units (ICUs) are unknown.
In March-May 2007, 120 Scandinavian ICUs were invited to answer a web-based survey consisting of 18 questions on types of colloids, indications, contraindications and rationale of use.
Seventy-three ICUs, of which 31 were university hospital units, answered the questionnaire. Most ICUs used both synthetic and natural colloids, and hydroxyethyl starch (HES) 130/0.4 was the preferred colloid in 59 units. Eleven ICUs had protocols for colloid use. The most frequent indication was second-line fluid for hypovolaemia, but one in three ICUs used colloids as first-line fluid. Thirty-five ICUs had contraindications, which were mainly for the use of synthetic colloids (acute renal failure 25 units, bleeding 15 units). Most units based the use of colloids on theoretical knowledge and tradition. Sixty-five and 54 ICUs were ready to change colloid use based on data from randomised trials of ICU patients showing changes in mortality or renal function, respectively.
Most Scandinavian ICUs use both synthetic and natural colloids, but HES 130/0.4 is by far the preferred colloid. Few units have protocols for colloid use, but most use them for hypovolaemia, and the majority have no contraindications. Most ICUs are ready to change colloid use if randomised trials in ICU patients show changes in mortality or renal function.
液体复苏是重症监护中常见的干预措施。胶体溶液被广泛使用,但近期数据表明其中一些溶液可能有害。这就需要对此进行更多的临床研究,但目前斯堪的纳维亚重症监护病房(ICU)对胶体溶液使用的偏好尚不清楚。
2007年3月至5月,邀请了120个斯堪的纳维亚ICU回答一项基于网络的调查问卷,该问卷包含18个关于胶体溶液类型、适应证、禁忌证及使用理由的问题。
73个ICU回复了问卷,其中31个是大学医院的科室。大多数ICU同时使用合成胶体和天然胶体,59个科室首选的胶体是羟乙基淀粉(HES)130/0.4。11个ICU有胶体溶液使用方案。最常见的适应证是作为低血容量的二线液体,但三分之一的ICU将胶体溶液用作一线液体。35个ICU有禁忌证,主要是针对合成胶体的使用(急性肾衰竭25个科室,出血15个科室)。大多数科室使用胶体溶液是基于理论知识和传统。分别有65个和54个ICU愿意根据针对ICU患者的随机试验数据改变胶体溶液的使用,这些数据显示死亡率或肾功能有变化。
大多数斯堪的纳维亚ICU同时使用合成胶体和天然胶体,但HES 130/0.4是目前首选的胶体。很少有科室有胶体溶液使用方案,但大多数用其治疗低血容量,且大多数没有禁忌证。如果针对ICU患者的随机试验显示死亡率或肾功能有变化,大多数ICU愿意改变胶体溶液的使用。