Kim Sun Min, Lee Sung Hoon, Suh Kahp Yang
Department of Mechanical Engineering, Inha University, 253 Young Hyun-dong, Nam-gu, Incheon 402-751, Republic of Korea.
Lab Chip. 2008 Jul;8(7):1015-23. doi: 10.1039/b800835c. Epub 2008 May 15.
An overview of the use of physically modified microfluidic channels towards cell research is presented. The physical modification can be realized either by combining embedded physical micro/nanostructures or a topographically patterned substrate at the micro- or nanoscale inside a channel. After a brief description of the background and the importance of the physically modified microfluidic system, various fabrication methods are described based on the materials and geometries of physical structures and channels. Of many operational principles for microfluidics (electrical, magnetic, optical, mechanical, and so on), this review primarily focuses on mechanical operation principles aided by structural modification of the channels. The mechanical forces are classified into (i) hydrodynamic, (ii) gravitational, (iii) capillary, (iv) wetting, and (v) adhesion forces. Throughout this review, we will specify examples where necessary and provide trends and future directions in the field.
本文概述了物理改性微流控通道在细胞研究中的应用。物理改性可通过在通道内部的微米或纳米尺度上结合嵌入式物理微/纳米结构或地形图案化基板来实现。在简要描述物理改性微流控系统的背景和重要性之后，根据物理结构和通道的材料及几何形状描述了各种制造方法。在微流控的众多操作原理（电、磁、光、机械等）中，本综述主要关注通过通道结构改性辅助的机械操作原理。机械力分为：（i）流体动力，（ii）重力，（iii）毛细管力，（iv）润湿性，和（v）粘附力。在本综述中，我们将在必要时列举实例，并提供该领域的趋势和未来方向。
