Bleyer H, Möritz K U, Grisk A
Acta Biol Med Ger. 1976;35(1):87-92.
Adenylate cyclase [ATP-pyrophosphatelyase (cyclizing) EC 4.6.1.1.] from ventricular muscles and the cerebrum of rats can be inhibited by diisopropylphosphofluoridate (DFP) and paraxone in concentrations from 10(-7) - 10(-9)M, and by dimethoate in concentrations from 10(-5) - 10(-7)M. The cAMP content in the heart diminished after i.p. 1.44 mg/kg DFP by 59.9%, and in the cerebrum by 68.2%. The depletion of cAMP caused by double LD50 DFP in the rat heart can be influenced neither by atropine alone, nor in combination with TMB-4. The results are discussed with regard to a possible action mechanism.
大鼠心室肌和大脑中的腺苷酸环化酶[ATP-焦磷酸裂解酶（环化），EC 4.6.1.1]可被浓度为10(-7)-10(-9)M的二异丙基氟磷酸酯（DFP）和对氧磷抑制，以及被浓度为10(-5)-10(-7)M的乐果抑制。腹腔注射1.44mg/kg DFP后，心脏中的cAMP含量减少了59.9%，大脑中的减少了68.2%。大鼠心脏中由两倍LD50 DFP引起的cAMP耗竭，既不受单独阿托品的影响，也不受与TMB-4联合使用的影响。针对可能的作用机制对结果进行了讨论。
