Swithers Susan E, McCurley Melissa, Hamilton Erica, Doerflinger Alicia
Department of Psychological Sciences and Ingestive Behavior Research Center, Purdue University, West Lafayette, IN 47907-1364, USA.
Horm Behav. 2008 Aug;54(3):471-7. doi: 10.1016/j.yhbeh.2008.05.009. Epub 2008 May 24.
Adult male rats have been demonstrated to increase food intake in response to administration of drugs that interfere with oxidation of fatty acids (e.g. methyl palmoxirate and mercaptoacetate [MA]), effects that are larger in animals maintained on a high-fat diet. In contrast, while administration of MA has been reported to stimulate food intake in pre-pubertal female rats, food intake is not stimulated by MA in adult female rats. Instead, administration of MA to adult females results in changes in reproductive behavior and physiology. The present experiments were designed to examine the effects of administration of MA on food intake in adult female rats. The results demonstrated that, as previously reported, food intake was stimulated by MA in adult male rats on low-fat and high-fat diets, but food intake was not stimulated by MA in gonadally-intact adult female rats on either low-fat or high-fat diet. Further, MA did not stimulate food intake in female rats ovariectomized as adults. However, when females were ovariectomized prior to the onset of puberty (postnatal day 25-28), food intake was stimulated by administration of MA in adulthood. Finally, cyclic injections of 17-beta-estradiol benzoate given to females ovariectomized prior to the onset of puberty abolished the stimulatory effects of MA on food intake in adult females. Taken together, the data suggest that exposure to estrogens during the time of puberty in female rats can persistently alter adult ingestive responding to signals related to changes in energy utilization.
成年雄性大鼠已被证明，给予干扰脂肪酸氧化的药物（如甲基棕榈酰氧肟酸酯和巯基乙酸[MA]）后，其食物摄入量会增加，在高脂饮食喂养的动物中这种影响更大。相比之下，虽然有报道称给予MA会刺激青春期前雌性大鼠的食物摄入量，但成年雌性大鼠对MA没有这种反应。相反，给成年雌性大鼠注射MA会导致其生殖行为和生理发生变化。本实验旨在研究给成年雌性大鼠注射MA对其食物摄入量的影响。结果表明，如先前报道的那样，MA会刺激低脂和高脂饮食喂养的成年雄性大鼠的食物摄入量，但不会刺激性腺完整的成年雌性大鼠（无论低脂还是高脂饮食）的食物摄入量。此外，MA也不会刺激成年后卵巢切除的雌性大鼠的食物摄入量。然而，当雌性大鼠在青春期开始前（出生后第25 - 28天）进行卵巢切除时，成年后给予MA会刺激其食物摄入量。最后，给青春期开始前卵巢切除的雌性大鼠周期性注射苯甲酸雌二醇会消除MA对成年雌性大鼠食物摄入量的刺激作用。综上所述，数据表明雌性大鼠在青春期接触雌激素会持续改变成年后对与能量利用变化相关信号的摄食反应。
