Singer-Koegler L K, Magluyan P, Ritter S
Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman 99164-6520, USA.
Physiol Behav. 1996 Jul;60(1):321-3. doi: 10.1016/0031-9384(95)02142-6.
The present study examined the feeding responses stimulated by low suprathreshold and optimal doses of 2-DG and MA in three groups of rats maintained and tested on low (4.3%), medium (13.5%), or high (66.4%) fat diets. Results show that diet alters the response to 2-DG and MA. Rats on the low-fat diet significantly increased food intake after both the low and high doses of 2-DG. Rats on the medium- and high-fat diet significantly increased food intake after both the low and high doses of 2-DG. Rats on the medium- and high-fat diets significantly increased food intake only after the high dose of 2-DG. After administration of the low and high doses of MA, rats on the high-fat diet ate significantly more. However, rats on the low- and medium-fat diets significantly increased food intake only after the high dose of MA. These results suggest that diet-induced dependence of rats on fat or carbohydrate metabolism alters the sensitivity of systems controlling food intake in response to deficits in the availability of these specific metabolic fuels.
本研究检测了在以低（4.3%）、中（13.5%）或高（66.4%）脂肪饮食维持并进行测试的三组大鼠中，低阈上剂量和最佳剂量的2-脱氧葡萄糖（2-DG）及甲硫氨酸（MA）所刺激的进食反应。结果表明，饮食会改变对2-DG和MA的反应。低脂饮食的大鼠在低剂量和高剂量的2-DG后，食物摄入量均显著增加。中脂和高脂饮食的大鼠在低剂量和高剂量的2-DG后，食物摄入量均显著增加。中脂和高脂饮食的大鼠仅在高剂量的2-DG后，食物摄入量显著增加。在给予低剂量和高剂量的MA后，高脂饮食的大鼠进食量显著增加。然而，低脂和中脂饮食的大鼠仅在高剂量的MA后，食物摄入量显著增加。这些结果表明，饮食诱导的大鼠对脂肪或碳水化合物代谢的依赖性改变了控制食物摄入的系统对这些特定代谢燃料可利用性不足的反应敏感性。
