Wang S W, Wang M, Grossman B M, Martin R J
Department of Foods and Nutrition, University of Georgia, Athens 30602-3622.
Physiol Behav. 1994 Sep;56(3):517-22. doi: 10.1016/0031-9384(94)90295-x.
The present study was designed to investigate (a) whether dietary fat manipulation, quantitatively and/or qualitatively, may influence the transport of fatty acids into the brain and oxidation of fatty acids in the hypothalamus; and (b) if an inhibitor of fatty acid oxidation changed food intake on these diets. Rats were fed for 4 wk 5% or 34% corn oil or tallow diets that were isocaloric and isonitrogenous. It was found that rats fed corn oil diets had significantly higher brain uptake index of palmitate than did rats fed tallow diets. In a second experiment, rats were fed either 30% corn oil or tallow diets and injected with either saline or mercaptoacetate (MA). Both saturated fat diets and mercaptoacetate injection reduced lateral hypothalamic, but not ventromedial hypothalamic fatty acid oxidation. Mercaptoacetate increased food intake only in the corn oil fed rats. It is proposed that these uptake and metabolic changes contribute to alterations in either energy expenditure or feeding behavior.
（a）饮食脂肪在数量和/或质量上的操控是否会影响脂肪酸向大脑的转运以及下丘脑脂肪酸的氧化；（b）脂肪酸氧化抑制剂是否会改变这些饮食条件下的食物摄入量。给大鼠喂食4周等热量、等氮的5%或34%玉米油或牛脂饮食。结果发现，喂食玉米油饮食的大鼠棕榈酸的脑摄取指数显著高于喂食牛脂饮食的大鼠。在第二个实验中，给大鼠喂食30%玉米油或牛脂饮食，并注射生理盐水或巯基乙酸（MA）。饱和脂肪饮食和注射巯基乙酸均降低了下丘脑外侧而非腹内侧的脂肪酸氧化。巯基乙酸仅增加了喂食玉米油大鼠的食物摄入量。研究提出，这些摄取和代谢变化有助于能量消耗或进食行为的改变。
