Shi Zumin, Hu Xiaoshu, He Ka, Yuan Baojun, Garg Manohar
Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China.
Nutrition. 2008 Oct;24(10):977-84. doi: 10.1016/j.nut.2008.05.002. Epub 2008 Jun 30.
Inflammation and iron deficiency are two important causes of anemia. Magnesium intake is inversely associated with inflammation. However, little is known as to whether magnesium intake is related to anemia. We assessed the joint association of magnesium and iron intake with anemia among Chinese adults.
A cross-sectional household survey of 2849 men and women 20 y of age or older was conducted in 2002. Nutrient intakes were assessed by 3-d weighed food records. Serum ferritin and hemoglobin concentrations were measured.
The prevalence of anemia was 18.3% in men and 31.5% in women. Magnesium and iron intakes were positively associated with hemoglobin levels and inversely related to the prevalence of anemia. The risks of anemia were reduced by 26% (P for trend = 0.03) and 52% (P < 0.01), respectively, for iron and magnesium intake comparing the fourth quartile with the first with adjustment for potential confounders. The lowest risk of anemia was observed among participants with the highest intakes of magnesium and iron (odds ratio 0.46, 95% confidence interval 0.31-0.68). The inverse association of iron intake and anemia but not the association of magnesium intake and anemia was modified by serum ferritin levels. The observed relations were not appreciably modified by gender.
This study suggests that magnesium is a potent predictor of anemia in Chinese adults.
炎症和缺铁是贫血的两个重要原因。镁的摄入量与炎症呈负相关。然而，关于镁的摄入量是否与贫血有关却知之甚少。我们评估了中国成年人中镁和铁的摄入量与贫血的联合关联。
2002年对2849名20岁及以上的男性和女性进行了一项横断面家庭调查。通过3天的食物称重记录评估营养素摄入量。测量血清铁蛋白和血红蛋白浓度。
男性贫血患病率为18.3%，女性为31.5%。镁和铁的摄入量与血红蛋白水平呈正相关，与贫血患病率呈负相关。在对潜在混杂因素进行调整后，将铁和镁摄入量的第四个四分位数与第一个四分位数进行比较，贫血风险分别降低了26%（趋势P值 = 0.03）和52%（P < 0.01）。在镁和铁摄入量最高的参与者中观察到贫血风险最低（比值比0.46，95%置信区间0.31 - 0.68）。血清铁蛋白水平改变了铁摄入量与贫血的负相关关系，但未改变镁摄入量与贫血的关系。观察到的关系在性别方面没有明显改变。
本研究表明镁是中国成年人贫血的一个有力预测指标。
