Huang Jungao, Xu Jing, Ye Ping, Xin Xiaoqin
Ganzhou Maternal and Child Health Hospital, Ganzhou, Jiangxi, China.
Department of Clinical Laboratory, Ganzhou People's Hospital, Ganzhou, Jiangxi, China.
Front Nutr. 2023 Feb 23;10:1046749. doi: 10.3389/fnut.2023.1046749. eCollection 2023.
Magnesium deficiency is related to an increased risk of anemia, but epidemiological evidence supporting this association remains scarce. The purpose of the present survey was to evaluate the relationship between dietary magnesium intake and the risk of anemia.
In total, 13,423 participants aged 20-80 years were enrolled using data from the National Health and Nutrition Examination Survey 2011-2016. Magnesium consumption was evaluated using 24 h dietary recalls. Multivariable generalized linear models were developed to demonstrate the association between dietary magnesium intake and the prevalence of anemia.
An inverse association between dietary magnesium intake and the risk of anemia was detected based on a full adjustment model. We evaluated magnesium intake as a categorical variable (five quartiles). Compared with the lowest value, the highest multivariate adjusted odds ratio (95% confidence interval) for anemia was 0.64 (0.46-0.89). Stratified analyses revealed a reverse relationship between magnesium intake and anemia in women. However, no significant association was observed in men ( = 0.376). A similar reverse association was found among the older group (aged ≥60 years).
Magnesium deficiency is closely related to a higher rate of anemia occurrence, especially among women and older Americans. Further larger-scale prospective studies are required to confirm these conclusions.
镁缺乏与贫血风险增加有关，但支持这种关联的流行病学证据仍然稀少。本调查的目的是评估膳食镁摄入量与贫血风险之间的关系。
利用2011 - 2016年美国国家健康和营养检查调查的数据，共纳入了13423名年龄在20 - 80岁之间的参与者。通过24小时膳食回顾来评估镁的摄入量。建立多变量广义线性模型以证明膳食镁摄入量与贫血患病率之间的关联。
基于完全调整模型，检测到膳食镁摄入量与贫血风险之间存在负相关。我们将镁摄入量作为分类变量（五个四分位数）进行评估。与最低值相比，贫血的最高多变量调整优势比（95%置信区间）为0.64（0.46 - 0.89）。分层分析显示女性中镁摄入量与贫血之间存在反向关系。然而，在男性中未观察到显著关联（P = 0.376）。在老年组（年龄≥60岁）中也发现了类似的反向关联。
镁缺乏与较高的贫血发生率密切相关，尤其是在女性和美国老年人中。需要进一步开展更大规模的前瞻性研究来证实这些结论。
