黄果西番莲对大鼠血液成分放射性标记、红细胞形态及高锝酸钠生物分布的影响。
Effects of Passiflora edulis flavicarpa on the radiolabeling of blood constituents, morphology of red blood cells and on the biodistribution of sodium pertechnetate in rats.
作者信息
Rebello B M, Moreno S R F, Godinho C R, Neves R F, Fonseca A S, Bernardo-Filho M, Medeiros A C
机构信息
Programa de Pós-Graduação em Ciências da Saúde, Universidade Federal do Rio Grande no Norte, Rio Grande do Norte, Brasil.
出版信息
Appl Radiat Isot. 2008 Dec;66(12):1788-92. doi: 10.1016/j.apradiso.2008.05.004. Epub 2008 May 21.
The aim of this study was to evaluate possible effects of Passiflora edulis flavicarpa (P. flavicarpa) extract on the labeling of blood constituents with (99m)Tc, on the morphology of red blood cells, and on the biodistribution of sodium pertechnetate (sodium (99m)Tc). Male Wistar rats were treated with either P. flavicarpa extract or 0.9% NaCl. After that, radiolabeling of blood constituents, morphological analysis of red blood cells and biodistribution of sodium (99m)Tc was evaluated. Radiolabeling of blood constituents and shape of red blood cells were not modified, but a significant (p<0.05) alteration of the biodistribution of sodium (99m)Tc was observed after treatment with P. flavicarpa extract. Although our results were obtained with animals, they could contribute to reduce the risk of misdiagnosis and/or repetition of the examinations in nuclear medicine.
本研究的目的是评估黄果西番莲（P. flavicarpa）提取物对血液成分用（99m）Tc标记、对红细胞形态以及对高锝酸钠（（99m）Tc 钠）生物分布的可能影响。雄性 Wistar 大鼠分别用 P. flavicarpa 提取物或 0.9% NaCl 进行处理。之后，评估血液成分的放射性标记、红细胞的形态分析以及（99m）Tc 钠的生物分布。血液成分的放射性标记和红细胞的形状未发生改变，但在用 P. flavicarpa 提取物处理后，观察到（99m）Tc 钠的生物分布有显著（p<0.05）改变。尽管我们的结果是在动物身上获得的，但它们可能有助于降低核医学中误诊和/或重复检查的风险。
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